| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
|
| | KPU-300 Basic information |
| Product Name: | KPU-300 | | Synonyms: | KPU-300;2,5-Piperazinedione, 3-[(3-benzoylphenyl)methylene]-6-(2-pyridinylmethylene)-, (3Z,6Z)- | | CAS: | 1620692-60-5 | | MF: | C24H17N3O3 | | MW: | 395.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1620692-60-5.mol |  |
| | KPU-300 Chemical Properties |
| Melting point | 263-266 °C | | Boiling point | 774.3±60.0 °C(Predicted) | | density | 1.324±0.06 g/cm3(Predicted) | | pka | 10.85±0.20(Predicted) |
| | KPU-300 Usage And Synthesis |
| Description | KPU-300 is a potent and selective antimicrotubule agent. KPU-300 exhibited a potent cytotoxicity with an IC50 value of 7.0 nM against HT-29 cells, by strongly binding to tubulin (K d = 1.3 μM) and inducing microtubule depolymerization. | | Uses | KPU-300 (compound 6b) is a tubulin inhibitor. KPU-300 has potent cytotoxicity with an IC50 value of 7.0 nM against HT-29 cells[1]. | | References | [1] Yoshiki Hayashi, et al. Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure. ACS Med Chem Lett. 2014 Jul 23;5(10):1094-8. DOI:10.1021/ml5001883 |
| | KPU-300 Preparation Products And Raw materials |
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