2-Chloro-4'-hydroxyacetophenone

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2-Chloro-4'-hydroxyacetophenone Basic information
Product Name:2-Chloro-4'-hydroxyacetophenone
Synonyms:4-hydroxyphenacylchloride;chlorophenacyle;p-(chloroacetyl)phenol;2-Chloro-1-(4-hydroxy-phenyl)ethanone;Acetophenone, 2-chloro-4'-hydroxy-;Brn 2086326;Einecs 228-613-0;Ethanone, 2-chloro-1-(4-hydroxyphenyl)-
CAS:6305-04-0
MF:C8H7ClO2
MW:170.59
EINECS:228-613-0
Product Categories:
Mol File:6305-04-0.mol
2-Chloro-4'-hydroxyacetophenone Structure
2-Chloro-4'-hydroxyacetophenone Chemical Properties
Melting point 145-146 °C
Boiling point 241.44°C (rough estimate)
density 1.2315 (rough estimate)
refractive index 1.5100 (estimate)
storage temp. Storage temp. 2-8°C
pka7.72±0.15(Predicted)
AppearanceWhite to off-white Solid
CAS DataBase Reference6305-04-0(CAS DataBase Reference)
EPA Substance Registry SystemEthanone, 2-chloro-1-(4-hydroxyphenyl)- (6305-04-0)
Safety Information
HS Code 2914790090
MSDS Information
2-Chloro-4'-hydroxyacetophenone Usage And Synthesis
Uses2-Chloro-1-(4-hydroxy-phenyl)-ethanone is a reagent that is used in the preparation of hydroxypyrimidine derivatives and their HDAC (histone deacetylases) inhibitory activity.
PreparationAlso obtained by reaction of acetyl chloride with anisole in the presence of aluminium chloride in n-heptane at 35° for 4 h 30 min (20%).
2-Chloro-4'-hydroxyacetophenone Preparation Products And Raw materials
Preparation Products4-Hydroxyphenylacetone-->Methyl 4-hydroxyphenylacetate
Tag:2-Chloro-4'-hydroxyacetophenone(6305-04-0) Related Product Information
Apremilast APST-ZA (R)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide (S)-N-(2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide Apremilast Impurity 4 Ethanone, 2-chloro-1-(3,5-dihydroxyphenyl)- (S)-N-(2-(1-(3,4-dihydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide 6H,12H-Indazolo[2,1-a]indazole-1,7-dicarboxylic acid, 6,12-dioxo- 3-oxo-1,3-dihydro-benzo[c]isoxazole-4-carboxylic acid Apremilast Impurity 3 1,2-Benzenedicarboxylicacid,3-(hydroxyamino)-(9CI) Apremilast 3,5-Cyclohexadiene-1,2-dione, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]- 1H-Indole-3,5,6-triol, 2,3-dihydro-1-(1-methylethyl)- (9CI) (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethanaMine Ipratropium bromide monohydrate Apremilast 2-Chloro-2',4'-dihydroxyacetophenone