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AZ7550 hydrochloride manufacturers
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| | AZ7550 hydrochloride Basic information |
| Product Name: | AZ7550 hydrochloride | | Synonyms: | AZ7550 hydrochloride;EGFR,ErbB-1,Epidermal growth factor receptor,HER1,Drug Metabolite,AZ7550 hydrochloride,inhibit,AZ7550,AZ-7550,AZ 7550,Inhibitor,IGF-1R,AZ-7550 hydrochloride;RMA-291;Osimertinib N desmethyl impurity | | CAS: | 2309762-40-9 | | MF: | C??H??ClN?O? | | MW: | 522.05 | | EINECS: | | | Product Categories: | | | Mol File: | 2309762-40-9.mol |  |
| | AZ7550 hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 1.88 mg/mL (3.60 mM) | | form | Solid | | color | Light yellow to yellow |
| | AZ7550 hydrochloride Usage And Synthesis |
| Uses | AZ7550 hydrochloride is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM. | | References | [1] Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67. DOI:10.1021/jm500973a |
| | AZ7550 hydrochloride Preparation Products And Raw materials |
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