2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-

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2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- manufacturers
2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Basic information
Product Name:2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
Synonyms:2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-;3-[5-(Aminomethyl)-1-oxo-isoindolin-2-yl]piperidine-2,6-dione;3-[6-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione;Lenalidomide-5-aminomethyl;3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione?, Lenalidomide-5-aminomethyl;3-[5-(Aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
CAS:1010100-28-3
MF:C14H15N3O3
MW:273.29
EINECS:
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Mol File:1010100-28-3.mol
2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Structure
2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Chemical Properties
Boiling point 598.5±50.0 °C(Predicted)
density 1.400±0.06 g/cm3(Predicted)
pka10.70±0.40(Predicted)
Safety Information
MSDS Information
2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Usage And Synthesis
UsesLenalidomide-5-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC[1].
IC 50Cereblon
References[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
Tag:2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-(1010100-28-3) Related Product Information
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