YM-254890 manufacturers
- YM-254890
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- $1107.00
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2026-07-14
- CAS:568580-02-9
- Purity: 95.00%
- Supply Ability: 10g
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| | YM-254890 Basic information |
| Product Name: | YM-254890 | | Synonyms: | L-Threonine, N-acetyl-L-threonyl-(αR)-α-hydroxybenzenepropanoyl-2,3-didehydro-N-methylalanyl-L-alanyl-N-methyl-L-alanyl-(3R)-3-[[(2S,3R)-2-(acetylamino)-3-hydroxy-4-methyl-1-oxopentyl]oxy]-L-leucyl-N,O-dimethyl-, (7→1)-lactone;L-Threonine, N-acetyl-L-threonyl-(αR)-α-hydroxybenzenepropanoyl-2,3-didehydro-N-methylalanyl-L-alanyl-N-methyl-L-alanyl-(3R)-3-[[(2S,3R)-2-(acetylamino)-3-hydroxy-4-methyl-1-oxopentyl]oxy]-L-leucyl-N,;YM-254890 | | CAS: | 568580-02-9 | | MF: | C46H69N7O15 | | MW: | 960.09 | | EINECS: | | | Product Categories: | | | Mol File: | 568580-02-9.mol |  |
| | YM-254890 Chemical Properties |
| Boiling point | 1232.4±65.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 10 mg/ml) | | form | lyophilized solid | | pka | 12.52±0.70(Predicted) | | color | White or off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | YM-254890 Usage And Synthesis |
| Description | YM-254890 (568580-02-9) is a novel Gαq/11 inhibitor.1 U46619-induced platelet aggregation is inhibited but phorbol ester- or ionophore-induced aggregation is not2 (IC50 = 0.1-0.2 μM)1. It blocks Pasteurella multocida toxin-mediated activation of Gαq.3 A highly useful new tool for studying Gαq/11-coupled receptor signaling and resulting cellular events.4 | | Uses | YM-254890 is a selective inhibitor of Gαq. | | IC 50 | P2Y1 Receptor | | storage | Store at -20°C | | References | [1] JUN TAKASAKI. A novel Galphaq/11-selective inhibitor.[J]. The Journal of Biological Chemistry, 2004, 279 46: 47438-47445. DOI:10.1074/jbc.m408846200
[2] TOSHIO UEMURA. Biological properties of a specific Gαq/11 inhibitor, YM-254890, on platelet functions and thrombus formation under high-shear stress[J]. British Journal of Pharmacology, 2009, 148 1: 61-69. DOI:10.1038/sj.bjp.0706711
[3] JOACHIM H C ORTH. Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}q and G{alpha}12/13.[J]. The Journal of Biological Chemistry, 2005, 280 44: 36701-36707. DOI:10.1074/jbc.m507203200
[4] NORIKAZU MIZUNO Hiroshi I. Functions and regulatory mechanisms of Gq-signaling pathways.[J]. Neurosignals, 2009, 17 1: 42-54. DOI:10.1159/000186689
[5] DINESH KANKANAMGE. Melanopsin (Opn4) utilizes Gαi and Gβγ as major signal transducers.[J]. Journal of cell science, 2018, 131 11. DOI:10.1242/jcs.212910
[6] TONIO PERA. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines[J]. FASEB Journal, 2018, 32 2: 862-874. DOI:10.1096/fj.201700555r
[7] KASUN RATNAYAKE. Blue light excited retinal intercepts cellular signaling.[J]. Scientific Reports, 2018: 10207. DOI:10.1038/s41598-018-28254-8
[8] MARK B ZIMERING S G N. Schizophrenia Plasma Autoantibodies Promote “Biased Agonism” at the 5-Hydroxytryptamine 2A Receptor: Neurotoxicity is Positively Modulated by Metabotropic Glutamate 2/3 Receptor Agonism.[J]. Endocrinology, diabetes and metabolism journal, 2019, 3 4. |
| | YM-254890 Preparation Products And Raw materials |
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