英夫马芬净
| 中文名称 | 英夫马芬净 |
|---|---|
| 中文同义词 | 英夫马芬净;(1S,2R,3R,4AR,6AS,7R,8R,10AR,10BR,12AS)-3-乙酰氧基-13-羟基-1,6A,8,10A-四甲基-8-((R)-3-甲基丁-2-基)-2-(((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-1,3,4,6,6A,7,8,9,10,10A,10B,11,12,12A-十四氢-2H-1,4A-(甲氧基甲氧基)苯并菲-7-羧酸;化合物 ENFUMAFUNGIN;Enfumafungin #天然产物 HY-N8537;Enfumafungin #天然产物 HY-N8537;恩富马芬金;恩麻芬净 |
| 英文名称 | Enfumafungin |
| 英文同义词 | 4H-1,4a-Propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid, 14-(acetyloxy)-8-[(1R)-1,2-dimethylpropyl]-15-(β-D-glucopyranosyloxy)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-4-hydroxy-1,6a,8,10a-tetramethyl-, (1S,4aR,6aS,7R,8R,10aR,10bR,12aS,14R,15R)-;(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aS)-3-acetoxy-13-hydroxy-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid;enfumafungin;(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aS)-3-Acetoxy-13-hydroxy-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid;(1R,5S,6R,7R,10R,11R,14S,15S,20R,21R)-20-(acetyloxy)-18-hydroxy-5,7,10,15-tetramethyl-7-[(2R)-3-methylbutan-2-yl]-21-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-17-oxapentacyclo[13.3.3.01,1?.02,11.0?,1?]henicos-2-ene-6-carboxylic acid;Enmofungin;(1S,4aR,6aS,7R,8R,10aR,10bR,12aS,14R,15R)-14-(Acetyloxy)-8-[(1R)-1,2-dimethylpropyl]-15-(β-D-glucopyranosyloxy)-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-4-hydroxy-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid (ACI) |
| CAS号 | 260979-95-1 |
| 分子式 | C38H60O12 |
| 分子量 | 708.89 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 260979-95-1.mol |
| 结构式 |  |
英夫马芬净 性质
| 沸点 | 813.5±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.31±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | Chloroform: Slightly Soluble DMSO: Soluble Methanol: Slightly Soluble |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.67±0.70(Predicted) |
| 颜色 | 白色至米白色 |
| InChIKey | IAOFPTKYKOAKGZ-POFOAJDFNA-N |
英夫马芬净是一种具有抗真菌特性的三萜类化合物，可用于医药合成。它的半合成衍生物伊布瑞克芬格 (ibrexafungerp)已获得美国食品药品监督管理局 (FDA) 批准，成为首个用于治疗侵袭性外阴念珠菌病的口服抗真菌药物。Enfumafungin，一种三萜糖苷，是从 Hormonema 内生物种的提取物中分离得到的。Enfumafungin 是一种抗真菌化合物，可作为 (1,3)-beta-D-葡聚糖合酶抑制剂作用在真菌细胞壁上。Enfumafungin 对酵母和真菌（隐球菌除外）具有特异性，不抑制枯草芽孢杆菌的生长。
(1,3)-beta-D-glucan synthase
Enfumafungin (24-48 h) has MICs of less than 0.5 μg/mL against the Candida and Aspergillus species tested and it is inactive against Cryptococcus , including the decapsulated form (MY2062).
Enfumafungin (50-200 mg/kg; i.p. twice daily for 2 days) produces a significant decrease in the number of c.f.u. in kidneys of mice challenged with C. albicans , with an ED 90 of 90 mg/kg.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-N8537R | 英夫马芬净 Enfumafungin (Standard) | 260979-95-1 | 5 mg | 2700元 |
| 2026/06/05 | HY-N8537 | 英夫马芬净 Enfumafungin | 260979-95-1 | 5 mg | 1200元 |