AAPK-25 manufacturers
- AAPK-25
-
- $52.00
-
2026-07-27
- CAS:2247919-28-2
- Purity: 97.79%
- Supply Ability: 10g
- AAPK-25
-
- $52.00
-
2026-07-27
- CAS:2247919-28-2
- Purity: 97.79%
- Supply Ability: 10g
- AAPK-25
-
- $87.00
-
2025-04-28
- CAS:2247919-28-2
- Purity: 97.79%
- Supply Ability: 10g
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| | AAPK-25 Basic information |
| Product Name: | AAPK-25 | | Synonyms: | AAPK-25;2-Naphthalenecarboxamide, 6-[(3,4-dichlorobenzoyl)amino]-N-2-thiazolyl-;Aurora Kinase,inhibit,Polo-like Kinase (PLK),AAPK 25,Apoptosis,Inhibitor,AAPK25,AAPK-25;AAPK-25, 10 mM in DMSO;6-(3,4-Dichlorobenzamido)-N-(thiazol-2-yl)-2-naphthamide | | CAS: | 2247919-28-2 | | MF: | C21H13Cl2N3O2S | | MW: | 442.32 | | EINECS: | | | Product Categories: | | | Mol File: | 2247919-28-2.mol |  |
| | AAPK-25 Chemical Properties |
| density | 1.536±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 6.98±0.70(Predicted) | | color | Off-white to light yellow |
| | AAPK-25 Usage And Synthesis |
| Uses | AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM[1]. | | in vivo | AAPK-25 enhances survival rate in the BALB/c nude mice tumor xenograft model[1]. | | References | [1] Qi B, et al. Discovery of inhibitors of Aurora/PLK targets as anti-cancer agents. J Med Chem. 2019 Aug 5. DOI:10.1021/acs.jmedchem.9b00353 |
| | AAPK-25 Preparation Products And Raw materials |
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