YKL-06-062 manufacturers
- YKL-06-062
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- $56.00
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2026-07-14
- CAS:2172617-16-0
- Purity: 99.95%
- Supply Ability: 10g
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| | YKL-06-062 Basic information |
| Product Name: | YKL-06-062 | | Synonyms: | YKL-06-062;Pyrimido[4,5-d]pyrimidin-2(1H)-one, 1-cyclohexyl-3-(2,6-dimethylphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-;YKL06062,YKL 06 062;1-Cyclohexyl-3-(2,6-dimethylphenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one;YKL-06-062, 10 mM in DMSO | | CAS: | 2172617-16-0 | | MF: | C31H39N7O | | MW: | 525.69 | | EINECS: | | | Product Categories: | | | Mol File: | 2172617-16-0.mol |  |
| | YKL-06-062 Chemical Properties |
| Boiling point | 706.2±70.0 °C(Predicted) | | density | 1.229±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 7.90±0.42(Predicted) | | color | Light yellow to yellow |
| | YKL-06-062 Usage And Synthesis |
| Description | YKL-06-062 is a second-generation SIK inhibitor. YKL 06-062 induces significant pigmentation after 8 days of treatment (1×/day). YKL 06-062 did not require mechanical application (rubbing) to induce significant human epidermal darkening. YKL-06-062 induces not only synthesis of melanin but also melanosomal maturation, export, and localization features, even after import into keratinocytes. | | Uses | YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively[1]. | | References | [1] Mujahid N, et al. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 Jun 13;19(11):2177-2184. DOI:10.1016/j.celrep.2017.05.042 |
| | YKL-06-062 Preparation Products And Raw materials |
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