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| | A-18-F-NH2 Basic information |
| Product Name: | A-18-F-NH2 | | Synonyms: | A-18-F-NH2;ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE AMIDE;ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2;H-ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2;A18Famide;A-18-F-NH2;H-ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2;Morphine Modulating Neuropeptide;PubChem ID: 16131005 | | CAS: | 99588-52-0 | | MF: | C89H130N24O24 | | MW: | 1920.13 | | EINECS: | | | Product Categories: | | | Mol File: | 99588-52-0.mol |  |
| | A-18-F-NH2 Chemical Properties |
| density | 1.48±0.1 g/cm3(Predicted) | | storage temp. | -15°C | | pka | 4.43±0.10(Predicted) |
| | A-18-F-NH2 Usage And Synthesis |
| Uses | Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects[1][2]. | | in vivo | Neuropeptide AF (cattle) (0.25 μg/2 μL; i.c.v.; 30 min prior to the tests) decreases the immobility time and increases the climbing and swimming times in modified mouse forced swimming test (mFST)[2].
| Animal Model: | Male CFLP mice (25-28 g)[2] | | Dosage: | 0.25 μg/2 μL | | Administration: | i.c.v.; 30 min prior to the tests | | Result: | Decreased the immobility time and increased the climbing and swimming times.
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| | References | [1] Nada Abdellah, et al. Neuropeptide AF Induces Piecemeal Degranulation in Murine Mucosal Mast Cells: A New Mediator in Neuro-Immune Communication in the Intestinal Lamina Propria Anat Rec (Hoboken). 2018 Jun;301(6):1103-1114. DOI:10.1002/ar.23780
[2] Miklós Palotai, et al. Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice. Behav Brain Res. 2014 Nov 1;274:264-9. DOI:10.1016/j.bbr.2014.08.007 |
| | A-18-F-NH2 Preparation Products And Raw materials |
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