3-(2-Ethylphenyl)-2-mercaptoquinazolin-4(3H)-one

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3-(2-Ethylphenyl)-2-mercaptoquinazolin-4(3H)-one manufacturers
3-(2-Ethylphenyl)-2-mercaptoquinazolin-4(3H)-one Basic information
Product Name:3-(2-Ethylphenyl)-2-mercaptoquinazolin-4(3H)-one
Synonyms:3-(2-ethylphenyl)-2-sulfanylidene-1H-quinazolin-4-one;4(1H)-Quinazolinone, 3-(2-ethylphenyl)-2,3-dihydro-2-thioxo-;Thioxodihydroquinazolinone 19;Thioxodihydroquinazolinone19;Thioxodihydroquinazolinone-19;3-(2-Ethylphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone;3-(2-Ethylphenyl)-2-mercaptoquinazolin-4(3H)-one
CAS:177951-34-7
MF:C16H14N2OS
MW:282.36
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Mol File:Mol File
3-(2-Ethylphenyl)-2-mercaptoquinazolin-4(3H)-one Structure
3-(2-Ethylphenyl)-2-mercaptoquinazolin-4(3H)-one Chemical Properties
Boiling point 437.9±38.0 °C(Predicted)
density 1.32±0.1 g/cm3(Predicted)
pka10.97±0.20(Predicted)
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MSDS Information
3-(2-Ethylphenyl)-2-mercaptoquinazolin-4(3H)-one Usage And Synthesis
DescriptionThioxodihydroquinazolinone-19 is an inducer of apoptotic cell death in platinum-resistant A2780cis human ovarian cancer cells. It acts by exhibiting a strong inhibitory effect in ovarian CSC-LCs in combination with cisplatin.
UsesAnticancer agent 173 (compound 19) is a potent thioxodihydroquinazolinone analogs when combined with platinum drugs in inducing apoptotic cancer cells death[1].
References[1] Jing Ma, et al. Combination of a thioxodihydroquinazolinone with cisplatineliminates ovarian cancer stem cell-like cells (CSC-LCs) andshows preclinical potential. Oncotarget. 2017 Dec 26;9(5):6042-6054. DOI:10.18632/oncotarget.23679
3-(2-Ethylphenyl)-2-mercaptoquinazolin-4(3H)-one Preparation Products And Raw materials
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