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| | OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE Basic information |
| Product Name: | OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE | | Synonyms: | [1,3]Oxazolo[4,5-b]pyridin-2-thiol;Oxazolo[4,5-b]pyridine-2(3H)-thione;1,3-Oxazolo[4,5-b]pyridin-2(3H)thione;2,3-Dihydro-2-thioxo-1,3-oxazolo[4,5-b]pyridine;Oxazolo[4,5-b]pyridin-2(3H)thione,99%;3H-[1,3]oxazolo[4,5-b]pyridine-2-thione;OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE;OXAZOLO[4,5-B]PYRIDINE-2-THIOL | | CAS: | 53052-06-5 | | MF: | C6H4N2OS | | MW: | 152.17 | | EINECS: | | | Product Categories: | | | Mol File: | 53052-06-5.mol | ![OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE Structure](CAS/GIF/53052-06-5.gif) |
| | OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE Chemical Properties |
| Melting point | 243-246 °C | | density | 1.402 (estimate) | | refractive index | 1.6430 (estimate) | | storage temp. | 2-8°C | | form | solid | | Appearance | White to off-white Solid | | CAS DataBase Reference | 53052-06-5 |
| Hazard Codes | Xi | | Safety Statements | 24/25 | | HazardClass | IRRITANT | | HS Code | 2934999090 |
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ACROS
| English |
| | OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE Usage And Synthesis |
| Chemical Properties | Beige crystalline powder | | Synthesis | Step 1: Synthesis of oxazolo[4,5-b]pyridine-2(3H)thione
2-Amino-3-hydroxypyridine (5.0 g, 45.45 mmol) and potassium ethylxanthate (8.0 g, 49.99 mmol) were dissolved in pyridine (50 mL), and the reaction was stirred at 110 °C overnight. Upon completion of the reaction, the mixture was cooled to 0 °C, ice water was added and acidified with concentrated hydrochloric acid. The precipitated solid was collected by filtration and dried under vacuum to afford the target product oxazolo[4,5-b]pyridine-2(3H)thione (6.0 g, 86.95% yield).
Product characterization data:
1H NMR (DMSO-d6, 300 MHz): δ 8.24-8.22 (d, 1H), 7.90-7.87 (d, 1H), 7.30-7.26 (m, 1H).
LCMS: m/z 153.0 [M + H]+. | | References | [1] Patent: WO2015/104688, 2015, A1. Location in patent: Page/Page column 36
[2] Patent: US2016/340366, 2016, A1. Location in patent: Paragraph 0205; 0206
[3] Monatshefte fur Chemie, 2011, vol. 142, # 9, p. 895 - 899
[4] Journal of Organic Chemistry, 1995, vol. 60, # 17, p. 5721 - 5725
[5] European Journal of Medicinal Chemistry, 2005, vol. 40, # 1, p. 15 - 23 |
| | OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE Preparation Products And Raw materials |
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