1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE manufacturers
|
| | 1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE Basic information |
| Product Name: | 1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE | | Synonyms: | TIMTEC-BB SBB009151;1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE;1H-INDOLE-3-CARBOHYDRAZIDE;ART-CHEM-BB B000103;BUTTPARK 148\07-47;CHEMBRDG-BB 3000103;1H-indole-3-carbohydrazide(SALTDATA: FREE);Indole-3-carboxylic acid hydrazide | | CAS: | 15317-58-5 | | MF: | C9H9N3O | | MW: | 175.19 | | EINECS: | | | Product Categories: | | | Mol File: | 15317-58-5.mol |  |
| | 1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE Chemical Properties |
| Melting point | 224-226 °C (decomp) | | density | 1.353±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Sparingly), Ethanol (Slightly, Heated, Sonicated) | | form | Solid | | pka | 13.07±0.30(Predicted) | | color | Pale Yellow to Pale Beige |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26 | | HazardClass | IRRITANT | | HS Code | 2933998090 |
| | 1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE Usage And Synthesis |
| Synthesis | GENERAL PROCEDURE: Methyl indole-3-carboxylate (5 mmol) was slowly added to hydrazine hydrate (80%, 3 mL) at room temperature. Subsequently, the reaction mixture was subjected to continuous microwave irradiation at 300 W for 5-8 min. The reaction process was monitored by thin layer chromatography (TLC). Once the reaction was complete, the mixture was cooled sufficiently to room temperature to afford the intermediate indole-3-carbohydrazide in 83-98% yield. | | References | [1] Journal of Chemical Research, 2015, vol. 39, # 5, p. 296 - 299
[2] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 22 - 32
[3] Chemistry of Heterocyclic Compounds, 1982, vol. 18, # 3, p. 258 - 261
[4] Pharmazie, 2017, vol. 72, # 12, p. 707 - 713
[5] Chemistry of Heterocyclic Compounds, 2009, vol. 45, # 10, p. 1270 - 1275 |
| | 1H-INDOLE-3-CARBOXYLIC ACID HYDRAZIDE Preparation Products And Raw materials |
|