- MeOSuc-AAPV-pNA
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- $113.00
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2026-07-15
- CAS:70967-90-7
- Purity:
- Supply Ability: 10g
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| | N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide Basic information |
| Product Name: | N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide | | Synonyms: | N-(METHOXYSUCCINYL)-L-ALANYL-L-ALANYL-L-PROLYL-L-VALINE 4-NITROANILIDE;ELASTASE SUBSTRATE I, COLORIMETRIC;MEO-SUC-ALA-ALA-PRO-VAL-PARANITROANILIDE;METHOXYSUCCINYL-ALA-ALA-PRO-VAL-P-NITROANILIDE;METHOXYSUCCINYL-ALA-ALA-PRO-VAL-P-NITROANILIDE, METHANOL ADDUCT;L-Valinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-;N-methoxysuccinyl-alanyl-alanyl-prolyl-valine-4-nitroanilide;N(methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine NA | | CAS: | 70967-90-7 | | MF: | C27H38N6O9 | | MW: | 590.63 | | EINECS: | 232-670-7 | | Product Categories: | | | Mol File: | 70967-90-7.mol |  |
| | N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide Chemical Properties |
| Melting point | 203-205°C | | Boiling point | 958.4±65.0 °C(Predicted) | | density | 1.297±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMF: 25 mg/mL, clear, light yellow | | form | Off-white solid | | pka | 13.29±0.20(Predicted) | | color | White to Off-White | | Appearance | White Solid | | Water Solubility | water: 1mg/mL | | BRN | 6266359 | | InChIKey | YEGSVRNITOBIRO-OSAZLGQLSA-N | | SMILES | C(N)(=O)[C@H](C(C)C)N(C(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCC(OC)=O)C1=CC=C([N+]([O-])=O)C=C1 |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 10-21 | | Storage Class | 11 - Combustible Solids |
| | N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide Usage And Synthesis |
| Description | Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy pathogens. Evaluating these enzymes is helpful to understanding inflammatory autoimmune processes. MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3, but not cathepsin G or chymotrypsin. Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm. | | Uses | N-Methoxysuccinyl-Ala-Ala-Pro-Val p-Nitroanilide is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3 but not cathespin. | | References | [1] OLAF WIESNER . Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments[J]. FEBS Letters, 2005, 579 24: Pages 5305-5312. DOI: 10.1016/j.febslet.2005.08.056
[2] B. KORKMAZ. Discriminating between the Activities of Human Neutrophil Elastase and Proteinase 3 Using Serpin-derived Fluorogenic Substrates*[J]. The Journal of Biological Chemistry, 2002, 7 1: 39074-39081. DOI: 10.1074/jbc.m202918200 | | Sequene | MeOSuc-Ala-Ala-Pro-Val-pNA |
| | N-Methoxysuccinyl-Ala-Ala-Pro-Val p-nitroanilide Preparation Products And Raw materials |
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