| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
|
| | AP-5 LITHIUM SALT Basic information |
| Product Name: | AP-5 LITHIUM SALT | | Synonyms: | DL-2-AMINO-5-PHOSPHONOVALERIC ACIDLITHIU M;DL-2-Amino-5-phosphonopentanoic acid, AP-5;DL-2-AMino-5-phosphonovaleric acid lithiuM salt ~95%;DL-2-AMINO-5-PHOSPHONOVALERIC ACID LITHIUM SALT;DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID LITHIUM SALT;AP-5 LITHIUM SALT;DL-2-Amino-5-phosphonovaleric acid lithium salt;DL-AP5 lithium | | CAS: | 125229-62-1 | | MF: | C5H11LiNO5P | | MW: | 203.06 | | EINECS: | | | Product Categories: | | | Mol File: | 125229-62-1.mol |  |
| | AP-5 LITHIUM SALT Chemical Properties |
| form | powder | | color | white to off-white | | InChI | 1S/C5H12NO5P.Li.H/c6-4(5(7)8)2-1-3-12(9,10)11;;/h4H,1-3,6H2,(H,7,8)(H2,9,10,11);; | | InChIKey | QIVHTKSFMZBERS-UHFFFAOYSA-N | | SMILES | [Li].NC(CCCP(O)(O)=O)C(O)=O |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | AP-5 LITHIUM SALT Usage And Synthesis |
| Uses | DL-AP5 (2-APV) lithium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 lithium shows significantly antinociceptive activity. DL-AP5 lithium specifically blocks on channels in the rabbit retina[1][2][3]. | | Biological Activity | DL-2-Amino-5-phosphonovaleric acid is a selective N-methyl-d-aspartate (NMDA) receptor antagonist used frequently in studies of neurological processes', 'Anticonvulsant; potent and selective antagonist for NMDA receptors. | | in vivo | DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA[3].
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin[4]. | Animal Model: | Male Wistar rats (180-230 g)[3] | | Dosage: | 1, 3.2 and 10 μg/rat | | Administration: | Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once | | Result: | Significantly decreased the effect of NMDA (10-2 μg/rat, intra-CA1) with significant interaction. |
| Animal Model: | Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4] | | Dosage: | 0, 2.5, 5, and 10 nmol; in a volume of 10 μL | | Administration: | Intracerebroventricular injection | | Result: | Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses. |
| Animal Model: | Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4] | | Dosage: | 5 nmol | | Administration: | Intracerebroventricular injection, followed by ghrelin (0.6 nmol) | | Result: | Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin. |
| | IC 50 | NMDA Receptor | | References | [1] Murray CW, et al. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44(2):179-185. DOI:10.1016/0304-3959(91)90135-K
[2] Massey SC, et al. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63(1):16-30. DOI:10.1152/jn.1990.63.1.16
[3] Jafari-Sabet M. NMDA receptor blockers prevents the facilitatory effects of post-training intra-dorsal hippocampal NMDA and physostigmine on memory retention of passive avoidance learning in rats. Behav Brain Res. 2006 Apr 25;169(1):120-7. DOI:10.1016/j.bbr.2005.12.011
[4] Taati M, et al. The effects of DL-AP5 and glutamate on ghrelin-induced feeding behavior in 3-h food-deprived broiler cockerels. J Physiol Biochem. 2011 Jun;67(2):217-23. DOI:10.1007/s13105-010-0066-y
[5] Chen T, et al. Glutamate-induced rapid induction of Arc/Arg3.1 requires NMDA receptor-mediated phosphorylation of ERK and CREB. Neurosci Lett. 2017 Nov 20;661:23-28. DOI:10.1016/j.neulet.2017.09.024 |
| | AP-5 LITHIUM SALT Preparation Products And Raw materials |
|