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| | 3,4-DIMETHOXYCHALCONE Basic information |
| Product Name: | 3,4-DIMETHOXYCHALCONE | | Synonyms: | LABOTEST-BB LT00454345;DIMETHOXYCHALCONE,3,4-;(E)-3-(3,4-DIMETHOXYPHENYL)-1-PHENYLPROP-2-EN-1-ONE;AKOS 220-38;3,4-DIMETHOXYCHALCONE;3-(3,4-DIMETHOXYPHENYL)-1-PHENYLPROP-2-EN-1-ONE;2-Propen-1-one, 3-(3,4-dimethoxyphenyl)-1-phenyl-;3,4 Dimethoxychalcone,3,4Dimethoxychalcone | | CAS: | 5416-71-7 | | MF: | C17H16O3 | | MW: | 268.31 | | EINECS: | | | Product Categories: | Chalcones | | Mol File: | 5416-71-7.mol |  |
| | 3,4-DIMETHOXYCHALCONE Chemical Properties |
| Melting point | 88°C | | Boiling point | 421.8±45.0 °C(Predicted) | | density | 1.128±0.06 g/cm3(Predicted) | | form | Solid | | color | Light yellow to green yellow |
| Provider | Language |
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ALFA
| English |
| | 3,4-DIMETHOXYCHALCONE Usage And Synthesis |
| Uses | 3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research[1]. | | in vivo | 3,4-Dimethoxychalcone (230 mg/kg for intraperitoneal injection) induces the nuclear translocation of TFEB and TFE3 of liver and heart tissues in Female C57/BL6 mice[1].
| | References | [1] Okolo EN, et al. New chalcone derivatives as potential antimicrobial and antioxidant agent. Sci Rep. 2021 Nov 5;11(1):21781. DOI:10.1038/s41598-021-01292-5
[2] Chen G, et al. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019 Nov 7;11(11):e10469. DOI:10.15252/emmm.201910469 |
| | 3,4-DIMETHOXYCHALCONE Preparation Products And Raw materials |
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