| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
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| | 4,4'-Dimethoxychalcone Basic information |
| Product Name: | 4,4'-Dimethoxychalcone | | Synonyms: | 1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE;2-Propen-1-one, 1,3-bis(4-methoxyphenyl)-;Ai3-25492;Nsc 87339;4,4'-DIMETHOXYBENZYLIDENEACETOPHENONE;DIMETHOXYCHALCONE,4,4'-;(E)-1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE;4,4'-Dimethoxychalcone,99% | | CAS: | 2373-89-9 | | MF: | C17H16O3 | | MW: | 268.31 | | EINECS: | | | Product Categories: | Chalcones | | Mol File: | 2373-89-9.mol |  |
| | 4,4'-Dimethoxychalcone Chemical Properties |
| Melting point | 101°C | | Boiling point | 444.6±45.0 °C(Predicted) | | density | 1.128±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: ≥ 250 mg/mL (931.76 mM) | | form | Solid | | color | Light yellow to yellow | | BRN | 1622293 | | CAS DataBase Reference | 2373-89-9(CAS DataBase Reference) |
| Provider | Language |
|
ALFA
| English |
| | 4,4'-Dimethoxychalcone Usage And Synthesis |
| Uses | 4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties[1]. | | in vivo | The flavonoid 4,4'-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species[1].
4,4'-Dimethoxychalcone (100mg/kg; intraperitoneally) efficiently triggered autophagic flux in the heart and liver from wild type (WT) C57BL/6 mice[1]. | Animal Model: | 6-week-old male wild type C57BL/6 or Atg4b-/- mice[1] | | Dosage: | 100mg/kg | | Administration: | Injected intraperitoneally with a single | | Result: | Triggered autophagic flux in the heart and liver. |
| | References | [1] Carmona-Gutierrez D, et al. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019 Feb 19;10(1):651. DOI:10.1038/s41467-019-08555-w |
| | 4,4'-Dimethoxychalcone Preparation Products And Raw materials |
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