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| | Cyclopentane-1,2-dicarboximude Basic information |
| Product Name: | Cyclopentane-1,2-dicarboximude | | Synonyms: | Gliclazide Impurity 18;N-methylcarbamic acid (2-acetylphenyl) ester;CYCLOPENTANE O-DICARBOXYLICIMIDE;SODIUM ACETATE TRIHYDRATE BP ACS USP;4,5,6,6a-Tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione;4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione;4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-quinone;Cyclopenta[c]pyrrole-1,3(2H,3aH)-dione, tetrahydro- | | CAS: | 5763-44-0 | | MF: | C7H9NO2 | | MW: | 139.15 | | EINECS: | 227-285-6 | | Product Categories: | Pharmaceutical Intermediates;J's;john's | | Mol File: | 5763-44-0.mol |  |
| | Cyclopentane-1,2-dicarboximude Chemical Properties |
| Melting point | 168 °C (dec.) | | Boiling point | 322.2±11.0 °C(Predicted) | | density | 1.242±0.06 g/cm3(Predicted) | | vapor pressure | 0.017-0.031Pa at 20-25℃ | | storage temp. | Sealed in dry,Room Temperature | | solubility | Acetonitrile (Slightly), Chloroform (Slightly) | | pka | 11.97±0.20(Predicted) | | form | Solid | | color | White to Off-White | | InChI | InChI=1S/C7H9NO2/c9-6-4-2-1-3-5(4)7(10)8-6/h4-5H,1-3H2,(H,8,9,10) | | InChIKey | QCWDCTDYSDJKTP-UHFFFAOYSA-N | | SMILES | N1C(=O)C2CCCC2C1=O | | Surface tension | 71.9mN/m at 1g/L and 20℃ |
| | Cyclopentane-1,2-dicarboximude Usage And Synthesis |
| Description | 1,2-cyclopentanediformylandne is the important intermediate of preparation gliclazide (Gliclazide).Gliclazide is s-generation sulfonylurea oral antidiabetic drug, be used for the treatment of non insulin dependent diabetes (type ii diabetes). | | Uses | 1,2-Cyclopentanedicarboximide was used as a reactant for [(benzopyranyl)amino]alkyl]azabicyclooctanedione anxiolytic, | | Synthesis | The general procedure for the synthesis of 1,2-cyclopentanedicarboxylic acid and formamide (CAS: 77287-34-4) as raw materials for the synthesis of 1,2-cyclopentanedicarboxylic acid is as follows: 50 g of 1,2-cyclopentanedicarboxylic acid and 15 g of formamide were mixed, and the reaction was carried out by raising the temperature up to 170 °C under the protection of nitrogen while evaporating the low-boiling by-products. The reaction progress was monitored by HPLC and terminated when the residual amount of raw material was less than 0.2%. After the reaction solution was cooled to 80 °C, 50 g of deionized water and 0.5 g of activated carbon were added and stirred at 50 °C for 30 min. The reaction mixture was thermally filtered and the filtrate was cooled to 20 °C and extracted with dichloromethane. The organic phase was concentrated to no fraction and dried at 90 °C. Subsequently 100 g of toluene was added, the mixture was cooled to 5 °C and dried under reduced pressure at 40 °C to give about 60.6 g of white crystal product. The yield of this step was 93.5% and the product was ≥99% pure and ≥98% content. | | Toxicity evaluation | Cyclopentane-1,2-dicarboximude has specific target organ toxicity, it causes skin irritation and serious eye irritation.
| | References | [1] Patent: CN106866495, 2017, A. Location in patent: Paragraph 0016; 0017; 0018; 0019; 0020 |
| | Cyclopentane-1,2-dicarboximude Preparation Products And Raw materials |
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