|
|
| | Thiodiglycolic Anhydride Basic information |
| Product Name: | Thiodiglycolic Anhydride | | Synonyms: | 2,2'-THIODIACETIC ACID ANHYDRIDE;1,4-OXATHIANE-2,6-DIONE;THIODIGLYCOLIC ANHYDRIDE;1-Oxa-4-thia-cyclohexan-2,6-dione;1,4-Oxathiane-2,6-dione~2,2-Thiodiacetic acid anhydride;1,4-Oxathiane-2,6-dione (Thiodiglycolic anhydride);1,4-OXATHIANE-2,6-DIONE
THIODIGLYCOLIC ANHYDRIDE;2,2'-Thiobisacetic anhydride | | CAS: | 3261-87-8 | | MF: | C4H4O3S | | MW: | 132.14 | | EINECS: | 608-761-6 | | Product Categories: | | | Mol File: | 3261-87-8.mol |  |
| | Thiodiglycolic Anhydride Chemical Properties |
| Melting point | 94 °C | | Boiling point | 158-159 °C(Press: 12 Torr) | | density | 1.468±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO, Methanol (Sparingly) | | form | Solid | | color | White to Off-White | | Sensitive | Moisture Sensitive | | BRN | 112528 | | InChI | InChI=1S/C4H4O3S/c5-3-1-8-2-4(6)7-3/h1-2H2 | | InChIKey | RIIUAPMWDSRBSH-UHFFFAOYSA-N | | SMILES | O1C(=O)CSCC1=O | | CAS DataBase Reference | 3261-87-8(CAS DataBase Reference) |
| Provider | Language |
|
ALFA
| English |
| | Thiodiglycolic Anhydride Usage And Synthesis |
| Chemical Properties | White needle-shaped crystal | | Uses | Thiodiglycolic Anhydride is used as a reagent in the synthesis of positively charged compounds as SERT inhibitors useful in the treatment of central nervous system (CNS) disorders. | | Synthesis | 3.0 g of 2,2'-thiodiacetic acid was accurately weighed in a 50 mL round bottom flask. To the flask was added 15 mL of acetic anhydride as reaction solvent. The reaction mixture was heated to 65 °C and kept at reflux for 4 hours. Upon completion of the reaction, the excess acetic anhydride and the by-product acetic acid were removed by distillation under reduced pressure. Subsequently, an appropriate amount of ether was added to the residue and the evaporation operation was repeated 2-3 times to purify the product. The final product was obtained as 2,2'-thiodiacetic anhydride in the form of a white solid powder and the product was dried at 40 °C overnight in 98.7% yield. | | References | [1] Patent: CN108245683, 2018, A. Location in patent: Paragraph 0051; 0053
[2] Organic Letters, 2015, vol. 17, # 15, p. 3930 - 3933
[3] Tetrahedron Letters, 2017, vol. 58, # 32, p. 3160 - 3163
[4] Tetrahedron Letters, 2002, vol. 43, # 8, p. 1519 - 1522
[5] Tetrahedron Letters, 2017, vol. 58, # 37, p. 3672 - 3677 |
| | Thiodiglycolic Anhydride Preparation Products And Raw materials |
|