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| | BW 723C86 Basic information |
| Product Name: | BW 723C86 | | Synonyms: | BW 723C86;BW 723C86 HYDROCHLORIDE;ALPHA-METHYL-5-(2-THIENYLMETHOXY)-1H-INDOLE-3-ETHANAMINE HYDROCHLORIDE;ALPHA-METHYL-5-(2-THIENYLMETHOXY)-1H-INDOLE-3-ETHANAMINE, MONOHYDROCHLORIDE;BW 723C86 \ 5-HT2B SEROTONIN RECEPTOR AG ONIST;a-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanaminehydrochloride;BW723C86HCl;a-Methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine Monohydrochloride | | CAS: | 160521-72-2 | | MF: | C16H19ClN2OS | | MW: | 322.85 | | EINECS: | | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Serotonin receptor | | Mol File: | 160521-72-2.mol |  |
| | BW 723C86 Chemical Properties |
| storage temp. | Desiccate at +4°C | | solubility | DMSO: >10 mg/mL | | form | solid | | color | white | | Water Solubility | H2O: 1mg/mL, clear | | InChI | 1S/C16H18N2OS.ClH/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14;/h2-6,8-9,11,18H,7,10,17H2,1H3;1H | | InChIKey | PYJBJMIBANAOFJ-UHFFFAOYSA-N | | SMILES | Cl.CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12 |
| WGK Germany | 3 | | RTECS | NL8504715 | | Storage Class | 11 - Combustible Solids |
| | BW 723C86 Usage And Synthesis |
| Uses | BW 723C86 is a selective 5-HT2B receptor agonist. It is used in the treatment of certain CNS disorders, in particular epilepsy, migraine and feeding disorders. | | Biological Activity | Selective 5-HT 2B receptor agonist. | | Biochem/physiol Actions | 5-HT2B serotonin receptor agonist. | | in vivo | BW-723C86 (1-20 mg/kg, s.c., 30 min pre-test (grooming)) causes hyperphagia and decreased grooming in rats, with increasing the time spent in feeding behaviour[2].
BW-723C86 (10-30 mg/kg, i.p. 30 min pre-test) shows anxiolytic effects in rats via 5-HT2B receptor[3].
BW-723C86 (3-10 mg/kg, s.c. 30 min pretest) exerts an appreciable anxiolytic-like profile in rats, with increasing total social interaction[4].
BW-723C86 (5 mg/kg, p.o., 20 or 30 min before the liquid meal) inhibits liquid meal-induced gastric accommodation in normal Hartley guinea pigs[5].
| Animal Model: | Male Sprague Dawley (CD) rats (220–250 g) for vogel conflict test[3] | | Dosage: | 0.3, 1, 3, 10, 30 mg/kg | | Administration: | Intraperitoneal injection (i.p.), 30 min pre-test | | Result: | Increased the number of punishments accepted in the rat Vogel conflict test over 3 min.
Had no significant effect on either the amount of time spent drinking or the latency to drink.
Did not affect apparent shock sensitivity.
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| | IC 50 | 5-HT2B Receptor | | storage | Desiccate at +4°C | | references | [1]. kennett ga, bright f, trail b, et al. effects of the 5-ht2b receptor agonist, bw 723c86, on three rat models of anxiety. br j pharmacol, 1996, 117(7): 1443-1448.
[2]. dergacheva o, wang x, kamendi h, et al. 5ht2 receptor activation facilitates p2x receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus. neuropharmacology, 2008, 54(7): 1095-1102.
[3]. kennett ga, trail b, bright f. anxiolytic-like actions of bw 723c86 in the rat vogel conflict test are 5-ht2b receptor mediated. neuropharmacology, 1998, 37(12): 1603-1610.
[4]. urtikova n, berson n, van steenwinckel j, et al. antinociceptive effect of peripheral serotonin 5-ht2b receptor activation on neuropathic pain. pain, 2012, 153(6): 1320-1331. |
| | BW 723C86 Preparation Products And Raw materials |
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