(S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE manufacturers
- (S)-(-)-HA 966
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- $837.00
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2026-05-11
- CAS:111821-58-0
- Purity:
- Supply Ability: 10g
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| | (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE Basic information |
| Product Name: | (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE | | Synonyms: | (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE;(S)-(-)-HA-966;S(-)-HA-966 S(-)-3-AMINO-1-HYDROX;(S)-(-)-3-Amino-1-hydroxypyrrolidine-2-one;(3S)-3-Amino-1-hydroxy-2-pyrrolidinone;(S)-3-Amino-1-hydroxy-2-pyrrolidinone;2-Pyrrolidinone, 3-amino-1-hydroxy-, (3S)-;(S) ( ) HA 966,(S)()HA 966 | | CAS: | 111821-58-0 | | MF: | C4H8N2O2 | | MW: | 116.12 | | EINECS: | | | Product Categories: | Glutamate receptor | | Mol File: | 111821-58-0.mol |  |
| | (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE Chemical Properties |
| Melting point | 166℃ | | Boiling point | 259℃ | | density | 1.436 | | Fp | 110℃ | | storage temp. | Store at RT | | pka | 7.19±0.20(Predicted) | | form | Powder | | color | Off-white to light yellow | | Water Solubility | Soluble to 100 mM in water |
| | (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE Usage And Synthesis |
| Uses | (S)-(-)-HA-966 is an NMDA antagonist/partial agonist and is a potent sedative with ataxic action. | | Biological Activity | Possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms. | | in vivo | (S)-(-)-HA 966 ((-)-HA 966; 3 and 5 mg/kg; i.p.) prevents restraint stress-induced dopamine utilization in both the medial prefrontal cortex and nucleus accumbens. (S)-(-)-HA 966 suppresses fear-induced behaviors: immobility and defecation[1].
(S)-(-)-HA 966 (3 mg/kg; i.p.) prevents locomotor sensitization without altering the acute motoric response elicited by cocaine[1].
(S)-(-)-HA 966 (5 mg/kg; i.p.) blocks acute cocaine-induced locomotion but resulted in sedation[1].
| | IC 50 | NMDA Receptor |
| | (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE Preparation Products And Raw materials |
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