FIDAS-5 manufacturers
- FIDAS-5
-
- $54.00
-
2026-08-19
- CAS:1391934-98-7
- Purity: 98.83%
- Supply Ability: 10g
- FIDAS-5
-
- $54.00
-
2026-08-19
- CAS:1391934-98-7
- Purity: 98.83%
- Supply Ability: 10g
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| | FIDAS-5 Basic information |
| Product Name: | FIDAS-5 | | Synonyms: | FIDAS-5;(E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline;p21WAF1/CIP1,S-adenosylmethionine,inhibit,MAT2A,anti-proliferation,SAH,Inhibitor,FIDAS-5,anti-cancer,CyclinD1,FIDAS5,c-Myc,SAM,FIDAS 5,colorectal;Benzenamine, 4-[(1E)-2-(2-chloro-6-fluorophenyl)ethenyl]-N-methyl-;FIDAS-5, 10 mM in DMSO | | CAS: | 1391934-98-7 | | MF: | C15H13ClFN | | MW: | 261.72 | | EINECS: | | | Product Categories: | | | Mol File: | 1391934-98-7.mol |  |
| | FIDAS-5 Chemical Properties |
| Boiling point | 385.1±30.0 °C(Predicted) | | density | 1.256±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 100mg/mL | | form | Solid | | pka | 4.44±0.38(Predicted) | | color | Light yellow to yellow | | InChI | InChI=1S/C15H13ClFN/c1-18-12-8-5-11(6-9-12)7-10-13-14(16)3-2-4-15(13)17/h2-10,18H,1H3/b10-7+ | | InChIKey | KXVXICBOMOGFMH-JXMROGBWSA-N | | SMILES | C1(NC)=CC=C(/C=C/C2=C(F)C=CC=C2Cl)C=C1 |
| WGK Germany | WGK 2 | | Storage Class | 11 - Combustible Solids |
| | FIDAS-5 Usage And Synthesis |
| Uses | FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities[1]. | | Biological Activity | Cell permeable: yes', 'Primary Target
MAT2A', 'Reversible: yes | | in vivo | FIDAS-5 (20 mg/kg; oral gavage; daily; for two weeks; athymic nude mice) treatment significantly inhibits the growth of xenograft tumors, with minimal difference in body weight[1].
Mice are treated with FIDAS-5 (20 mg/kg) for 1 week. The liver SAM levels are significantly reduced[1]. | Animal Model: | 16 athymic nude mice injected with HT29 CRC cells[1] | | Dosage: | 20 mg/kg | | Administration: | Oral gavage; daily; for two weeks | | Result: | Significantly inhibited the growth of xenograft tumors.
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| | References | [1] Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803. DOI:10.1021/cb3005353 |
| | FIDAS-5 Preparation Products And Raw materials |
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