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| | 1,3-Propanediamine, N3-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N1,N1-dimethyl- Basic information |
| Product Name: | 1,3-Propanediamine, N3-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N1,N1-dimethyl- | | Synonyms: | 1,3-Propanediamine, N3-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N1,N1-dimethyl-;RET-IN-3;N1-(3-(Benzo[d][1,3]dioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-N3,N3-dimethylpropane-1,3-diamine;RET-IN-3, 10 mM in DMSO | | CAS: | 2414374-53-9 | | MF: | C18H21N5O2 | | MW: | 339.39 | | EINECS: | | | Product Categories: | | | Mol File: | 2414374-53-9.mol | ![1,3-Propanediamine, N3-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N1,N1-dimethyl- Structure](CAS/20200611/GIF/2414374-53-9.gif) |
| | 1,3-Propanediamine, N3-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N1,N1-dimethyl- Chemical Properties |
| solubility | DMSO: Sparingly soluble: 1-10 mg/mL
Ethanol: Sparingly soluble: 1-10 mg/mL | | form | Solid | | color | Off-white to light yellow |
| | 1,3-Propanediamine, N3-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N1,N1-dimethyl- Usage And Synthesis |
| Description | RET-IN-3 is a is a selective RETV804M kinase inhibitor. | | Uses | RET-IN-3 (compound 34) is a selective RETV804M kinase inhibitor, with an IC50 of 19 nM[1]. | | References | [1] Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505. DOI:10.1021/acsmedchemlett.9b00615 |
| | 1,3-Propanediamine, N3-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-N1,N1-dimethyl- Preparation Products And Raw materials |
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