Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester manufacturers
- Boc-NH-PEG1-C2-Boc
-
-
2025-06-07
- CAS:145119-18-2
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
|
| | Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester Basic information |
| | Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester Chemical Properties |
| Boiling point | 384.2±22.0 °C(Predicted) | | density | 1.026±0.06 g/cm3(Predicted) | | pka | 12.22±0.46(Predicted) |
| | Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester Usage And Synthesis |
| Uses | N-Boc-PEG-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | Biological Activity | N-Boc-PEG-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-,1,1-dimethylethyl ester Preparation Products And Raw materials |
|