Methylamino-PEG1-t-butyl ester manufacturers
- MeNH-PEG1-COOtBu
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2025-06-07
- CAS:1807521-03-4
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | Methylamino-PEG1-t-butyl ester Basic information |
| Product Name: | Methylamino-PEG1-t-butyl ester | | Synonyms: | Methylamino-PEG1-t-butyl ester;tert-Butyl 3-[2-(methylamino)ethoxy]propanoate;Methylamino-PEG1-Boc;Propanoic acid, 3-[2-(methylamino)ethoxy]-, 1,1-dimethylethyl ester;MeNH-PEG1-COOtBu;Me-NH-PEG1-CH2CH2COOtBu | | CAS: | 1807521-03-4 | | MF: | C10H21NO3 | | MW: | 203.28 | | EINECS: | | | Product Categories: | | | Mol File: | 1807521-03-4.mol |  |
| | Methylamino-PEG1-t-butyl ester Chemical Properties |
| Boiling point | 266.7±15.0 °C(Predicted) | | density | 0.957±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DCM | | form | Liquid | | pka | 9.51±0.10(Predicted) | | color | Colorless to light yellow |
| | Methylamino-PEG1-t-butyl ester Usage And Synthesis |
| Description | Methylamino-PEG1-t-butyl ester is a PEG linker containing a methylamine group and a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Methylamino-PEG1-t-butyl ester Preparation Products And Raw materials |
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