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| | Benzamide, 2-fluoro-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]- Basic information |
| Product Name: | Benzamide, 2-fluoro-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]- | | Synonyms: | Benzamide, 2-fluoro-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-;2-fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide;Capmatinib M18 Metabolite;Capmatinib Metabolite | | CAS: | 1029713-99-2 | | MF: | C22H15FN6O | | MW: | 398.39 | | EINECS: | | | Product Categories: | | | Mol File: | 1029713-99-2.mol | ![Benzamide, 2-fluoro-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]- Structure](CAS/20210305/GIF/1029713-99-2.gif) |
| | Benzamide, 2-fluoro-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]- Chemical Properties |
| density | 1.47±0.1 g/cm3(Predicted) | | pka | 14.50±0.50(Predicted) |
| | Benzamide, 2-fluoro-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]- Usage And Synthesis |
| Uses | CNJ-294 is an intermediate in the synthesis of Capmatinib (HY-13404) and a metabolite of Capmatinib (HY-13404)[1][2]. | | References | [1] Qingquan Lian. Preparation method of carbamatinib. CN111825678 A. 2020-10-27.
[2] Glaenzel U, et al. Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite. Drug Metab Dispos. 2020 Oct;48(10):873-885. DOI:10.1124/dmd.119.090324 |
| | Benzamide, 2-fluoro-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]- Preparation Products And Raw materials |
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