7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate

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7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate Basic information
Product Name:7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate
Synonyms:FR 167653;FR 167653 sulfate;7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate
CAS:158876-66-5
MF:C24H20FN5O6S
MW:525.51
EINECS:
Product Categories:
Mol File:158876-66-5.mol
7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate Structure
7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate Chemical Properties
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate Usage And Synthesis
UsesFR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo[1][2][3].
in vivo

FR 167653 (FR 167653 sulfate) (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis[1].

Animal Model:Inbred male Balbuc mice (aged 8 weeks)[1]
Dosage:32 kg/mg
Administration:Subcutaneous injection; 24-48 hours
Result:The scores of acute tubular necrosis in FR-167653-treated mice were significantly lower in vehicle-treated mice at 24 and 48 h after ischaemiaureperfusion both in cortex and outer medulla.
References[1] Furuichi K, et al. Administration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice. Nephrol Dial Transplant. 2002 Mar;17(3):399-407. DOI:10.1093/ndt/17.3.399
[2] Iwata Y, et al. p38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice. J Am Soc Nephrol. 2003 Jan;14(1):57-67. DOI:10.1097/01.asn.0000037402.83851.5f
[3] Kawashima Y, et al. FR167653 attenuates ischemia and reperfusion injury of the rat lung with suppressing p38mitogen-activated protein kinase. J Heart Lung Transplant. 2001 May;20(5):568-74. DOI:10.1016/s1053-2498(01)00243-1
7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate Preparation Products And Raw materials
Tag:7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4-pyridinyl)-pyrazolo[5,1-c][1,2,4]triazine sulfate(158876-66-5) Related Product Information
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