- 1H-PYRAZOL-4-YLAMINE
-
- $0.00 / 1kg
-
2025-04-04
- CAS:28466-26-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- 1H-PYRAZOL-4-YLAMINE
-
- $1.00 / 1kg
-
2019-07-06
- CAS:28466-26-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 200kg
|
| | 1H-PYRAZOL-4-YLAMINE Basic information | | Form |
| | 1H-PYRAZOL-4-YLAMINE Chemical Properties |
| Melting point | 75-77°C | | Boiling point | 142.17°C (rough estimate) | | density | 1.0248 (rough estimate) | | refractive index | 1.5060 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | pka | 17.70±0.50(Predicted) | | form | powder to crystal | | color | White to Brown to Dark purple | | Sensitive | Hygroscopic | | InChI | InChI=1S/C3H5N3/c4-3-1-5-6-2-3/h1-2H,4H2,(H,5,6) | | InChIKey | AXINVSXSGNSVLV-UHFFFAOYSA-N | | SMILES | N1C=C(N)C=N1 | | CAS DataBase Reference | 28466-26-4 | | NIST Chemistry Reference | 4-NH2-pyrazole(28466-26-4) |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36/37 | | WGK Germany | 3 | | RTECS | UQ4993000 | | HazardClass | IRRITANT | | HS Code | 2933199090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 1H-PYRAZOL-4-YLAMINE Usage And Synthesis |
| Form | powder | | Chemical Properties | It is white to brownish-purple solid under normal temperature and pressure, with certain alkalinity, and can form salts with various acids. | | Uses | 4-Aminopyrazole, is a versatile building block for the preparation of pharmaceutical and biologically active compounds. 4-Amino-1H-pyrazole, has also shown to have anticonvulsant activity, and thus can be used in the treatment of epileptic seizures. | | Synthesis | 4-Nitropyrazole (1.13 g, 10 mmol) was dissolved in methanol (10 mL) under hydrogen (1 atm) atmosphere and 10% Pd-C catalyst (0.1 g) was added. The reaction mixture was stirred at 25 °C for 12 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 4-aminopyrazole (860 mg, yield: 100%), which could be used in subsequent reactions without further purification. | | References | [1] Patent: US2015/336982, 2015, A1. Location in patent: Paragraph 0252; 0253
[2] ChemMedChem, 2016, p. 1695 - 1699
[3] Patent: CN105418616, 2016, A. Location in patent: Paragraph 0118; 0119
[4] Organic and Biomolecular Chemistry, 2013, vol. 11, # 3, p. 395 - 399
[5] Patent: WO2017/178510, 2017, A1. Location in patent: Page/Page column 297 |
| | 1H-PYRAZOL-4-YLAMINE Preparation Products And Raw materials |
|