| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:S1PL-IN-31
CAS:1538574-95-6
Package:5mg/RMB 6560;10mg/RMB 11300;1mg/RMB 1730
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| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:S1PL-IN-31
|
| Company Name: |
Biosynth Biological Technology (Suzhou) Co Ltd
|
| Tel: |
51288865780 |
| Email: |
sales@biosynth.com |
| Products Intro: |
Product Name:6-[(2R)-4-[7-Chloro-4-(phenylmethyl)-1-phthalazinyl]-2-methyl-1-piperazinyl]-3-pyridinecarbonitrile
CAS:1538574-95-6
|
| Company Name: |
Neobioscience Co., Ltd.
|
| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:S1PL-IN-31
|
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| | 3-Pyridinecarbonitrile, 6-[(2R)-4-[7-chloro-4-(phenylmethyl)-1-phthalazinyl]-2-methyl-1-piperazinyl]- Basic information |
| | 3-Pyridinecarbonitrile, 6-[(2R)-4-[7-chloro-4-(phenylmethyl)-1-phthalazinyl]-2-methyl-1-piperazinyl]- Chemical Properties |
| Boiling point | 728.9±60.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | solubility | Acetonitrile: Soluble
DMSO: Soluble | | pka | 7.53±0.30(Predicted) |
| | 3-Pyridinecarbonitrile, 6-[(2R)-4-[7-chloro-4-(phenylmethyl)-1-phthalazinyl]-2-methyl-1-piperazinyl]- Usage And Synthesis |
| Description | S1PL-IN-31 is an inhibitor of the sphingosine-1-phosphate (S1P)-catabolizing enzyme S1P Lyase (S1PL) and an antagonist of the 7-transmembrane helical protein Smoothened. | | Uses | S1PL-IN-31 (compound ) is an oral active sphingosine-1-phosphate (S1P) lyase inhibitor with the IC50 of 210 nM. S1PL-IN-31 is Smoothened receptor antagonist with the IC50 of 440 nM. S1PL-IN-31 can be used for study of experimental autoimmune encephalomyelitis[1][2]. | | References | [1] Weiler S, et al. Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis. J Med Chem. 2014;57(12):5074-5084. DOI:10.1021/jm500338n
[2] Harris CM, et al. Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats. J Pharmacol Exp Ther. 2016;359(1):151-158. DOI:10.1124/jpet.116.235002 |
| | 3-Pyridinecarbonitrile, 6-[(2R)-4-[7-chloro-4-(phenylmethyl)-1-phthalazinyl]-2-methyl-1-piperazinyl]- Preparation Products And Raw materials |
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