SPHINGOSINE-1-PHOSPHATE LYASE INHIBITOR 31|||S1PL INHIBITOR 31|||S1P LYASE INHIBITOR 31
| 中文名称 | SPHINGOSINE-1-PHOSPHATE LYASE INHIBITOR 31|||S1PL INHIBITOR 31|||S1P LYASE INHIBITOR 31 |
|---|---|
| 中文同义词 | SPHINGOSINE-1-PHOSPHATE LYASE INHIBITOR 31|||S1PL INHIBITOR 31|||S1P LYASE INHIBITOR 31;化合物 S1PL-IN-31 |
| 英文名称 | 3-Pyridinecarbonitrile, 6-[(2R)-4-[7-chloro-4-(phenylmethyl)-1-phthalazinyl]-2-methyl-1-piperazinyl]- |
| 英文同义词 | 3-Pyridinecarbonitrile, 6-[(2R)-4-[7-chloro-4-(phenylmethyl)-1-phthalazinyl]-2-methyl-1-piperazinyl]-;S1PL-IN-31;6-[(2R)-4-[7-Chloro-4-(phenylmethyl)-1-phthalazinyl]-2-methyl-1-piperazinyl]-3-pyridinecarbonitrile |
| CAS号 | 1538574-95-6 |
| 分子式 | C26H23ClN6 |
| 分子量 | 454.95 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1538574-95-6.mol |
| 结构式 |  |
SPHINGOSINE-1-PHOSPHATE LYASE INHIBITOR 31|||S1PL INHIBITOR 31|||S1P LYASE INHIBITOR 31 性质
| 沸点 | 728.9±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.36±0.1 g/cm3(Predicted) |
| 溶解度 | Acetonitrile: Soluble DMSO: Soluble |
| 酸度系数(pKa) | 7.53±0.30(Predicted) |
S1PL-IN-31 (compound 31) 是一种具有口服活性的磷酸鞘氨醇裂解酶 (sphingosine-1-phosphate (S1P) lyase) 抑制剂，其 IC50 为210 nM。S1PL-IN-31 也是 Smo 受体拮抗剂，其 IC50 值为 440 nM。S1PL-IN-31 可用于实验性自身免疫性脑脊髓炎的研究。