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Product Name:Taurolithocholic acid-d4 sodium
CAS:2410279-97-7
Purity:98% HPLC Package:1mg;5mg;10mg;50mg
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ChemeGen
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Product Name:Taurolithocholic Acid-d4 sodium salt
CAS:2410279-97-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Reer Technology (Shanghai) Co., LTD
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Product Name:TAUROLITHOCHOLIC ACID, SODIUM SALT(2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL
CAS:2410279-97-7
Purity:98% Package:1 ML Remarks:DLM-9570-C
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CHINA ISOTOPE CO., LIMITED
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Product Name:Taurolithocholic Acid-d4 (sodium salt)
CAS:2410279-97-7
Purity:Purity: >=98% Package:1mg Remarks:CA32984
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| | Taurolithocholic Acid-d5 Basic information |
| Product Name: | Taurolithocholic Acid-d5 | | Synonyms: | 2-[[(3α,5β)-3-hydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid, monosodium salt;TAUROLITHOCHOLICACID,SODIUMSALT(2,2,4,4-D4) IN METHANOL;Taurolithocholic acid-d4 sodium;D4-Taurolithocholic Acid Sodium Salt;Taurolithocholic acid, sodium salt (2,2,4,4-D?, 98%);Taurolithocholic acid, sodium salt (2,2,4,4-D?, 98%) 100 μg/mL in methanol;Taurolithocholic Acid-[D4] Sodium Salt In Methanol, Concentration: 100μg/mL (Standard) | | CAS: | 2410279-97-7 | | MF: | C26H46NNaO5S | | MW: | 507.71 | | EINECS: | | | Product Categories: | | | Mol File: | 2410279-97-7.mol |  |
| | Taurolithocholic Acid-d5 Chemical Properties |
| storage temp. | -20°C | | solubility | DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml | | form | A crystalline solid | | CAS Number Unlabeled | 6042-32-6 |
| WGK Germany | WGK 2 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 |
| | Taurolithocholic Acid-d5 Usage And Synthesis |
| Description | Taurolithocholic acid-d4 (TLCA-d4) is intended for use as an internal standard for the quantification of TLCA by GC- or LC-MS. TLCA is a taurine-conjugated form of the secondary bile acid lithocholic acid .1 TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells.2 It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis.3,4 Serum levels of TLCA increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.1 | | Uses | Taurolithocholic acid-d4 (sodium) is the deuterium labeled Taurolithocholic acid (sodium salt). Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1]. | | References | 1. Schmid, A., Neumann, H., Karrasch, T., et al. Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS) PLoS One 11(2),e0148869(2016).
2. Rust, C., Wild, N., Bernt, C., et al. Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent J. Biol. Chem. 284(5),2908-2916(2009).
3. Denk, G.U., Maitz, S., Wimmer, R., et al. Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver Hepatology 52(5),1758-1768(2010).
4. Javitt, N.B. Cholestasis in rats induced by taurolithocholate Nature 210(5042),1262-1263(1966). |
| | Taurolithocholic Acid-d5 Preparation Products And Raw materials |
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