2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- manufacturers
- SMI-6860766
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- $550.00
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2026-07-31
- CAS:433234-16-3
- Purity: 99.90%
- Supply Ability: 10g
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| | 2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- Basic information |
| | 2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- Chemical Properties |
| Boiling point | 417.5±45.0 °C(Predicted) | | density | 1.509±0.06 g/cm3(Predicted) | | solubility | Acetonitrile: Slightly soluble: 0.1-1 mg/ml | | pka | -1.69±0.70(Predicted) |
| | 2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- Usage And Synthesis |
| Description | SMI-6860766 is a blocker of CD40-Traf6 interactions. It acts by ameliorating the complications of diet induced obesity in mice. | | Uses | SMI 6860766, a small molecule inhibitor of CD40-TRAF6 interaction, improves glucose tolerance, reduces immune cell accumulation in adipose tissue, and reduces AT inflammation[1]. | | in vivo | SMI 6860766 increases the number of adipocytes per field of view by 15.3% in mouse EpAT, indicating that SMI reduces adipocyte size, indicating reduces lipid storage and improves metabolic function[1].
SMI 6860766 reduces the number of total leukocytes (CD45+ cells) in mouse EpAT by 68.5%[1].
SMI 6860766 does not induce differences in hepatosteatosis[1]. | | References | [1] Van den Berg SM, et al. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes (Lond). 2015 May;39(5):782-90. DOI:10.1038/ijo.2014.198
[2] BARBARA ZARZYCKA. Discovery of Small Molecule CD40–TRAF6 Inhibitors[J]. Journal of Chemical Information and Modeling , 2015, 55 2: 294-307. DOI: 10.1021/ci500631e |
| | 2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- Preparation Products And Raw materials |
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