1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester manufacturers
- GRL-0496
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- $60.00
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2026-07-27
- CAS:1087243-14-8
- Purity: 99.90%
- Supply Ability: 10g
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| | 1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester Basic information |
| Product Name: | 1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester | | Synonyms: | 1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester;GRL-0496;chloropyridyl,GRL-0496,3CLpro,inhibit,GRL0496,Inhibitor,SARS-CoV,GRL 0496,SARS coronavirus;5-Chloropyridin-3-yl 1H-indole-4-carboxylate;GRL-0496, 10 mM in DMSO;5-Chloro-3-pyridinyl 1H-indole-4-carboxylate | | CAS: | 1087243-14-8 | | MF: | C14H9ClN2O2 | | MW: | 272.69 | | EINECS: | | | Product Categories: | | | Mol File: | 1087243-14-8.mol |  |
| | 1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester Chemical Properties |
| Boiling point | 483.9±35.0 °C(Predicted) | | density | 1.431±0.06 g/cm3(Predicted) | | storage temp. | -20° | | solubility | Soluble in DMSO (>30 mg/mL) and ethanol (>25 mg/mL) | | form | solid | | pka | 15.35±0.30(Predicted) | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | | InChIKey | BOSZJNSICHFHMA-UHFFFAOYSA-N | | SMILES | ClC1=CN=CC(OC(C2=CC=CC3=C2C=CN3)=O)=C1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester Usage And Synthesis |
| Description | GRL-0496 (1087243-14-8) is a potent (IC50= 30 nM in cell culture assays) inhibitor of severe acute respiratory syndrome-coronavirus chymotrypsin-like protease (SARS-CoV 3CLpro).1 | | Uses | GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1]. | | Definition | ChEBI: (5-Chloropyridin-3-yl) 1H-indole-4-carboxylate is an indolyl carboxylic acid. It has a role as an anticoronaviral agent. | | References | [1] ARUN K. GHOSH . Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18 20: Pages 5684-5688. DOI:10.1016/j.bmcl.2008.08.082 |
| | 1H-Indole-4-carboxylic acid, 5-chloro-3-pyridinyl ester Preparation Products And Raw materials |
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