4-Pentynoyl-Val-Ala-PAB-PNP

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4-Pentynoyl-Val-Ala-PAB-PNP Basic information
Product Name:4-Pentynoyl-Val-Ala-PAB-PNP
Synonyms:4-Pentynoyl-Val-Ala-PAB-PNP;L-Alaninamide, N-(1-oxo-4-pentynyl)-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
CAS:1956294-76-0
MF:C27H30N4O8
MW:538.55
EINECS:
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Mol File:1956294-76-0.mol
4-Pentynoyl-Val-Ala-PAB-PNP Structure
4-Pentynoyl-Val-Ala-PAB-PNP Chemical Properties
Boiling point 845.7±65.0 °C(Predicted)
density 1.290±0.06 g/cm3(Predicted)
pka13.30±0.70(Predicted)
Safety Information
MSDS Information
4-Pentynoyl-Val-Ala-PAB-PNP Usage And Synthesis
Uses4-Pentynoyl-Val-Ala-PAB-PNP is a cleavable ADC linker, that has been used to synthesis cryptophycin conjugates[1]. 4-Pentynoyl-Val-Ala-PAB-PNP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50Cleavable Linker
References[1] Cedric DESSIN, et al. Cryptophycin compounds and conjugates thereof. WO2022175222
4-Pentynoyl-Val-Ala-PAB-PNP Preparation Products And Raw materials
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