| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
- BTA-1
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- $1980.00
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2026-05-11
- CAS:439858-28-3
- Purity:
- Supply Ability: 10g
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| Product Name: | BTA-1 | | Synonyms: | BTA-1,2-(4′-Methylaminophenyl)benzothiazole;4-(1,3-Benzothiazol-2-yl)-N-methylaniline;(4-Benzothiazol-2-yl-phenyl)-methyl-amine;4-(Benzo[d]thiazol-2-yl)-N-methylaniline;Benzenamine, 4-(2-benzothiazolyl)-N-methyl- | | CAS: | 439858-28-3 | | MF: | C14H12N2S | | MW: | 240.33 | | EINECS: | | | Product Categories: | | | Mol File: | 439858-28-3.mol |  |
| | BTA-1 Chemical Properties |
| Boiling point | 415.5±47.0 °C(Predicted) | | density | 1.258±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble ~10mg/mL | | pka | 2.58±0.12(Predicted) | | form | solid | | color | yellow | | InChI | 1S/C14H12N2S/c1-15-11-8-6-10(7-9-11)14-16-12-4-2-3-5-13(12)17-14/h2-9,15H,1H3 | | InChIKey | FHJRKGXJBXPBGA-UHFFFAOYSA-N | | SMILES | CNc1ccc(cc1)-c2nc3ccccc3s2 |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids |
| | BTA-1 Usage And Synthesis |
| Description | BTA-1 is an uncharged derivative of thioflavin-T. It has high affinity for Aβ fibrils and shows very good brain entry and clearance. | | Uses | BTA-1 is an uncharged derivative of thioflavin-T. BTA-1 has a high affinity for Aβ fibrils and shows very good brain penetration and clearance[1]. | | Biochem/physiol Actions | BTA-1 is a probe for β-amyloid aggregates; fluorescent thioflavin-T derivative; exhibits high affinity for amyloid deposits; displays 50-fold higher affinity than thioflavin-T; selectively stains cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice, as well as Aβ fibrils in postmortem brain tissue obtained from AD patients; crosses the blood brain barrier. | | References | [1] Klunk WE, et al. The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J Neurosci. 2003;23(6):2086-2092. DOI:10.1523/JNEUROSCI.23-06-02086.2003 |
| | BTA-1 Preparation Products And Raw materials |
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