Butanamide, N-[(3,5-difluorophenyl)methyl]-N-hydroxy-2,2-dimethyl-

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Email: marketing@targetmol.com

Butanamide, N-[(3,5-difluorophenyl)methyl]-N-hydroxy-2,2-dimethyl- manufacturers
Butanamide, N-[(3,5-difluorophenyl)methyl]-N-hydroxy-2,2-dimethyl- Basic information
Product Name:Butanamide, N-[(3,5-difluorophenyl)methyl]-N-hydroxy-2,2-dimethyl-
Synonyms:Butanamide, N-[(3,5-difluorophenyl)methyl]-N-hydroxy-2,2-dimethyl-;RIP1 kinase inhibitor 5
CAS:2428422-17-5
MF:C13H17F2NO2
MW:257.28
EINECS:
Product Categories:
Mol File:2428422-17-5.mol
Butanamide, N-[(3,5-difluorophenyl)methyl]-N-hydroxy-2,2-dimethyl- Structure
Butanamide, N-[(3,5-difluorophenyl)methyl]-N-hydroxy-2,2-dimethyl- Chemical Properties
Boiling point 338.2±52.0 °C(Predicted)
density 1.195±0.06 g/cm3(Predicted)
pka9.05±0.50(Predicted)
Safety Information
MSDS Information
Butanamide, N-[(3,5-difluorophenyl)methyl]-N-hydroxy-2,2-dimethyl- Usage And Synthesis
UsesRIP1 kinase inhibitor 5 (example 1) is a potent inhibitor of RIP1, which is used as a checkpoint kinase to control tumor immunity[1]. RIP1 kinase inhibitor 5 is similar with SIR1-365 (compound 13), which inhibits necrosis and iron death activity[2].
References[1] Su Yaning, et al. Preparation of cyrstalline forms of RIP1 inhibitor. World Intellectual Property Organization, WO2023066368 A1. 2023-04-27.
[2] Su Yaning, et al. Preparation of substituted amides as RIP1 inhibitors. World Intellectual Property Organization, WO2020103859 A1. 2020-05-28.
Butanamide, N-[(3,5-difluorophenyl)methyl]-N-hydroxy-2,2-dimethyl- Preparation Products And Raw materials
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