Benzonitrile, 4-amino-3-methoxy- (9CI) manufacturers
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| | Benzonitrile, 4-amino-3-methoxy- (9CI) Basic information |
| | Benzonitrile, 4-amino-3-methoxy- (9CI) Chemical Properties |
| Melting point | 46-48 °C | | Boiling point | 297.5±30.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 1.66±0.10(Predicted) | | Appearance | Light yellow to brown Solid |
| HazardClass | IRRITANT | | HS Code | 2921420090 |
| | Benzonitrile, 4-amino-3-methoxy- (9CI) Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 3-methoxy-4-aminobenzonitrile from 3-methoxy-4-nitrobenzonitrile was as follows: 3-methoxy-4-nitrobenzonitrile (11.4 g, 64 mmol) was suspended in ethyl acetate (60 mL) and 10% Pd/C catalyst (1 g) was added. The reaction mixture was placed in a Parr reactor under hydrogen atmosphere and vigorously shaken at 50 psi for 45 min at room temperature. Upon completion of the reaction, the mixture was filtered through a short pad of diatomaceous earth and the filtrate was concentrated to afford 4-amino-3-methoxybenzonitrile as a yellow oil, which rapidly solidified to a solid (9.5 g, 95% yield). | | References | [1] Patent: US2011/130398, 2011, A1. Location in patent: Page/Page column 34
[2] Patent: US2011/269809, 2011, A1. Location in patent: Page/Page column 13
[3] Patent: US2012/46306, 2012, A1. Location in patent: Page/Page column 33
[4] Journal of Medicinal Chemistry, 2000, vol. 43, # 6, p. 1187 - 1202
[5] Patent: US5506252, 1996, A |
| | Benzonitrile, 4-amino-3-methoxy- (9CI) Preparation Products And Raw materials |
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