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| | [1,1'-Biphenyl]-4-carboxamide, N-(1-acetyl-1,2,3,4-tetrahydro-2,2,4-trimethyl-4-phenyl-6-quinolinyl)- Basic information |
| Product Name: | [1,1'-Biphenyl]-4-carboxamide, N-(1-acetyl-1,2,3,4-tetrahydro-2,2,4-trimethyl-4-phenyl-6-quinolinyl)- | | Synonyms: | [1,1'-Biphenyl]-4-carboxamide, N-(1-acetyl-1,2,3,4-tetrahydro-2,2,4-trimethyl-4-phenyl-6-quinolinyl)-;N-(1-Acetyl-2,2,4-trimethyl-4-phenyl-1,2,3,4-tetrahydroquinolin-6-yl)-[1,1'-biphenyl]-4-carboxamide;N-(1-Acetyl-2,2,4-trimethyl-4-phenyl-1,2,3,4-tetrahydroquinolin-6-yl)-[1,1'-biphenyl]-4-carboxamide;FSH receptor antagonist 1 | | CAS: | 487064-35-7 | | MF: | C33H32N2O2 | | MW: | 488.62 | | EINECS: | | | Product Categories: | | | Mol File: | 487064-35-7.mol | ![[1,1'-Biphenyl]-4-carboxamide, N-(1-acetyl-1,2,3,4-tetrahydro-2,2,4-trimethyl-4-phenyl-6-quinolinyl)- Structure](CAS/20210305/GIF/487064-35-7.gif) |
| | [1,1'-Biphenyl]-4-carboxamide, N-(1-acetyl-1,2,3,4-tetrahydro-2,2,4-trimethyl-4-phenyl-6-quinolinyl)- Chemical Properties |
| Boiling point | 634.8±55.0 °C(Predicted) | | density | 1.153±0.06 g/cm3(Predicted) | | pka | 12.63±0.60(Predicted) |
| | [1,1'-Biphenyl]-4-carboxamide, N-(1-acetyl-1,2,3,4-tetrahydro-2,2,4-trimethyl-4-phenyl-6-quinolinyl)- Usage And Synthesis |
| Uses | FSH receptor antagonist 1 (compound 10) is a potent antagonist of the G(s)-protein-coupled human follicle-stimulating hormone (FSH) receptor. FSH receptor antagonist 1 exhibits an IC50 of 28 nM on a cell line expressing the human FSH receptor. FSH receptor antagonist 1 significantly inhibits follicle growth and ovulation in an ex vivo mouse model[1]. | | References | [1] Straten NCR, et, al. Identification of substituted 6-amino-4-phenyltetrahydroquinoline derivatives: potent antagonists for the follicle-stimulating hormone receptor. J Med Chem. 2005 Mar 24;48(6):1697-700. DOI:10.1021/jm049676l |
| | [1,1'-Biphenyl]-4-carboxamide, N-(1-acetyl-1,2,3,4-tetrahydro-2,2,4-trimethyl-4-phenyl-6-quinolinyl)- Preparation Products And Raw materials |
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