2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)-

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2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)- Basic information
Product Name:2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)-
Synonyms:2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)-;N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-(phenylsulfonyl)piperidine-3-carboxamide;KCNQ1 activator-1;N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-(phenylsulfonyl)piperidine-2-carboxamide;1-(benzenesulfonyl)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]piperidine-2-carboxamide;KCNQ1 activator-1u00A0;KCNQ1 activator-1u00A0, 10 mM in DMSO
CAS:1008671-38-2
MF:C22H23N3O4S2
MW:457.57
EINECS:
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Mol File:1008671-38-2.mol
2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)- Structure
2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)- Chemical Properties
density 1.364±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (546.36 mM; Need ultrasonic)
pka8.37±0.70(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)- Usage And Synthesis
UsesKCNQ1 activator-1 (compound 3) is a potent activator of KCNQ1 channel. KCNQ1 activator-1 has the potential for the research of long QT syndrome (LQTS)[1].
Biological ActivityKCNQ1 activator-1 (compound 3) is a potent activator of KCNQ1 channel. KCNQ1 activator-1 has the potential for the research of long QT syndrome (LQTS)[1].
References[1]. Mattmann ME, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012;22(18):5936-5941.
2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)- Preparation Products And Raw materials
Tag:2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-(phenylsulfonyl)-(1008671-38-2) Related Product Information
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