|
|
| | Guanosine-5'-diphosphate disodium salt Basic information | | Uses |
| | Guanosine-5'-diphosphate disodium salt Chemical Properties |
| Melting point | >280°C (dec.) | | storage temp. | -20°C | | solubility | H2O: 50 mg/mL, clear, colorless | | form | Powder | | color | White | | biological source | Porcine brain
microbial (Corynebacterium sp)
synthetic | | Water Solubility | Soluble in water | | Stability: | Hygroscopic | | InChIKey | PVMPTWQLNDHIEV-NGPBCCOENA-N | | SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C=NC2C(NC(N)=NC1=2)=O)O.[NaH] |&1:1,2,3,15,r| |
| | Guanosine-5'-diphosphate disodium salt Usage And Synthesis |
| Uses | Guanosine 5'-diphosphate disodium salt is a useful research chemical. | | Uses | Guanosine-5'-diphosphate disodium salt is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors. It is also used to study cell signaling processes mediate by guanine nucleotide exchange factors. | | General Description | Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells. | | Biochem/physiol Actions | Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI). | | in vivo | Guanosine 5'-diphosphate disodium salt (30 mg/kg, i.p., a single dose for 24 h) combined with FeSO4 (2 mg/kg, i.p., a single dose for 24 h) suppresses the iron storage ferritin level, thus preventing Hepcidin (HY-P70400)-induced internalization of FPN with increased iron absorption in normal mice[2].
Guanosine 5'-diphosphate disodium salt (30 mL/kg, i.p., three times a week for two weeks) can improve turpentine-induced inflammatory anemia in mice[1].
| Animal Model: | Male BALB/c mice[2]. | | Dosage: | 30 mL/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Increased hemoglobin levels and serum iron levels in the long-term dosing model.
Decreased Hamp mRNA expression, and spleen iron content was reduced by 46% in the short-term dosing model. |
| | IC 50 | Human Endogenous Metabolite |
| | Guanosine-5'-diphosphate disodium salt Preparation Products And Raw materials |
|