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| | Petasitenine Basic information |
| Product Name: | Petasitenine | | Synonyms: | Petasitenine;PETASITINENE;(15R,20R)-15,20-Epoxy-15,20-dihydro-12-hydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione;Fukinotoxin【neutral】;Petasitenine【neutral】;C10359;Spiro[2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-4,2'-oxirane]-3,8,17-trione, 7-hydroxy-3',6,7,14-tetramethyl-, (1R,2'R,3'R,6R,7R)-;Petasitenine (Fukinotoxin) | | CAS: | 60102-37-6 | | MF: | C19H27NO7 | | MW: | 381.42 | | EINECS: | | | Product Categories: | | | Mol File: | 60102-37-6.mol |  |
| | Petasitenine Chemical Properties |
| Melting point | 129.5°C | | Boiling point | 508.82°C (rough estimate) | | density | 1.2977 (rough estimate) | | refractive index | 1.5180 (estimate) | | pka | 12.75±0.60(Predicted) | | color | Crystals from C6H6/hexane or Me2CO | | IARC | 3 (Vol. 31, Sup 7) 1987 |
| RIDADR | 1544 | | HazardClass | 6.1(b) | | PackingGroup | III | | Toxicity | mma-sat 1 mg/plate MUREAV 68,211,79 |
| | Petasitenine Usage And Synthesis |
| Description | A pyrrolizidine alkaloid, petasitenine occurs, together with neopetasitenine (q.v.)
in Petasites japonicus Maxim. Like the accompanying base, it possesses strong
hepatotoxic properties. | | Uses | Petasitenine (Fukinotoxin) is a pyrrolizidine alkaloid that can be found in the plant Petasites japonicus, which is a carcinogenic metabolite of neopetasitenine. Petasitenine causes lactate dehydrogenase leakage, and exhibits hepatotoxicity[1]. | | Definition | ChEBI: Petasitenine is a spiro-epoxide. | | Safety Profile | Questionable carcinogen with experimental carcinogenic data.Mutation data reported. Used as a food and herbal remedy. When heated to decomposition it emits toxic fumes of NOx. | | References | Yamada etal., Chem.Lett.,461 (1976) |
| | Petasitenine Preparation Products And Raw materials |
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