Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]-

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Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]- Suppliers list
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Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]- manufacturers
Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]- Basic information
Product Name:Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]-
Synonyms:Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]-;Aurora kinase inhibitor-8
CAS:2133001-88-2
MF:C30H29N7O3
MW:535.6
EINECS:
Product Categories:
Mol File:2133001-88-2.mol
Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]- Structure
Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]- Chemical Properties
density 1.340±0.06 g/cm3(Predicted)
storage temp. 4°C, away from moisture and light
form Solid
pka12.88±0.70(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]- Usage And Synthesis
DescriptionFMF-03-145-1 shows doese dependent inhibition of pAurora A (Aurora A substrate) and pH3 S10 (Aurora B substrate) in HCT116 cells. FMF-03-145-1 effects on the cell cycle are consistent with selective on-target inhibition.
UsesAurora kinase inhibitor-8 is a highly selective inhibitor of the Aurora kinases.
References[1] Ferguson FM, et al. Characterization of a highly selective inhibitor of the Aurora kinases. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4405-4408. DOI:10.1016/j.bmcl.2017.08.016
Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]- Preparation Products And Raw materials
Tag:Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]-(2133001-88-2) Related Product Information
Benzamide, N-[4-[(6,11-dihydro-5,8,11-trimethyl-6-oxo-5H-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]-4-[(1-oxopropyl)amino]- 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one 6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 2-chloro-5,11-dihydro-5,8,11-trimethyl- 2-chloro-11-Methyl-5H-benzo[e]pyriMido[5,4-b][1,4]diazepin-6(11H)-one 2-chloro-5,11-diMethyl-5H-benzo[e]pyriMido[5,4-b][1,4]diazepin-6(11H)-one Aurora-coMpound 1