4,7-Benzofurandione, 2-acetyl-6-[(4-methoxyphenyl)amino]- manufacturers
- STAT3-IN-10
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- $1520.00
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2026-05-11
- CAS:2499491-04-0
- Purity:
- Supply Ability: 10g
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| | 4,7-Benzofurandione, 2-acetyl-6-[(4-methoxyphenyl)amino]- Basic information |
| | 4,7-Benzofurandione, 2-acetyl-6-[(4-methoxyphenyl)amino]- Chemical Properties |
| Boiling point | 551.6±50.0 °C(Predicted) | | density | 1.390±0.06 g/cm3(Predicted) | | pka | -1.15±0.20(Predicted) |
| | 4,7-Benzofurandione, 2-acetyl-6-[(4-methoxyphenyl)amino]- Usage And Synthesis |
| Uses | STAT3-IN-10 is a STAT3 inhibitor with an IC50 value of 5.18 μM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces cancer cells apoptosis[1]. | | in vivo | STAT3-IN-10 (A11) (i.p.; 5, 10 mg/kg; once a day, 21 days) inhibits the growth of human xenograft tumor in vivo[1]. | Animal Model: | Five weeks old female BALB/c nude mice (16–18g) bearing inoculation of human breast cancer cells MDA-MB-231[1]. | | Dosage: | 5 and 10 mg/kg | | Administration: | IP, once a day, 21 days | | Result: | Inhibited the growth of human xenograft tumor in vivo without apparent body-weight loss for treated mice and inhibited the levels of p-STAT3 in tumor tissues. |
| | IC 50 | STAT3: 5.18 μM (IC50) | | References | [1] Kai-Rui Feng, et al. Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. Eur J Med Chem. 2020 Sep 1;201:112428. DOI:10.1016/j.ejmech.2020.112428 |
| | 4,7-Benzofurandione, 2-acetyl-6-[(4-methoxyphenyl)amino]- Preparation Products And Raw materials |
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