Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-

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Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- Basic information
Product Name:Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-
Synonyms:Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-
CAS:2281803-28-7
MF:C36H37F5IN9O6
MW:913.63
EINECS:
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Mol File:2281803-28-7.mol
Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- Structure
Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- Chemical Properties
density 1+-.0.1 g/cm3(Predicted)
pka4.46±0.10(Predicted)
Safety Information
MSDS Information
Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- Usage And Synthesis
UsesMEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC50 values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines[1].
IC 50MEK1: 124 ± 11 nM (IC50); PI3Kα: 130 ± 13 nM (IC50); PI3Kδ: 236 ± 29 nM (IC50); PI3Kβ: 1537 ± 188 nM (IC50); PI3Kγ: 2745 ± 485 nM (IC50)
References[1] Van Dort ME, et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2022 Feb 5;229:113996. DOI:10.1016/j.ejmech.2021.113996
Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- Preparation Products And Raw materials
Tag:Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-(2281803-28-7) Related Product Information
Benzamide, N-[[12-[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-14-hydroxy-3,6,9-trioxa-12-azatetradec-1-yl]oxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- Benzamide, N-[2-[2-[2-[2-[[4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- ST-168 Hyaluronic acid LY 294002 Hydrochloride RMC6236