Octanamide, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[4-(7-hydroxy-2-oxo-2H-1,3-benzoxazin-3(4H)-yl)phenyl]-

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Octanamide, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[4-(7-hydroxy-2-oxo-2H-1,3-benzoxazin-3(4H)-yl)phenyl]- Suppliers list
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Octanamide, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[4-(7-hydroxy-2-oxo-2H-1,3-benzoxazin-3(4H)-yl)phenyl]- manufacturers

  • MD13
  • MD13 pictures
  • 2026-07-29
  • CAS:
  • Purity:
  • Supply Ability: 10g
Octanamide, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[4-(7-hydroxy-2-oxo-2H-1,3-benzoxazin-3(4H)-yl)phenyl]- Basic information
Product Name:Octanamide, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[4-(7-hydroxy-2-oxo-2H-1,3-benzoxazin-3(4H)-yl)phenyl]-
Synonyms:MD13;MIF degrader MD13;Octanamide, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[4-(7-hydroxy-2-oxo-2H-1,3-benzoxazin-3(4H)-yl)phenyl]-
CAS:2758431-97-7
MF:C35H35N5O8
MW:653.68
EINECS:
Product Categories:
Mol File:2758431-97-7.mol
Octanamide, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[4-(7-hydroxy-2-oxo-2H-1,3-benzoxazin-3(4H)-yl)phenyl]- Structure
Octanamide, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[4-(7-hydroxy-2-oxo-2H-1,3-benzoxazin-3(4H)-yl)phenyl]- Chemical Properties
Boiling point 964.5±65.0 °C(Predicted)
density 1.434±0.06 g/cm3(Predicted)
solubility DMSO:65.37(Max Conc. mg/mL);100.0(Max Conc. mM)
pka8.85±0.20(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
Octanamide, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[4-(7-hydroxy-2-oxo-2H-1,3-benzoxazin-3(4H)-yl)phenyl]- Usage And Synthesis
DescriptionMD13, also known as MIF degrader MD13, is a potent MIF (macrophage migration inhibitory factor) Degrader (PROTAC) (DC50 < 100 nM; Dmax = 92% after 6 h). MD13 comprises the cereblon ligand Pomalidomide joined by a linker to a MIF inhibitor. MD13 reduces MIF levels, arrests cells at the G2/M phase and inhibits proliferation of A549 lung carcinoma cells. Growth of A549 cell 3D spheroids is also inhibited by MDF13.
UsesMD13 is a macrophage migration inhibitory factor (MIF)-directed PROTAC with a Ki of 71 nM. MD13 can be used for cancer research[1].
storageStore at -20°C
References[1] Xiao Z, et al. Proteolysis Targeting Chimera (PROTAC) for Macrophage Migration Inhibitory Factor (MIF) Has Anti-Proliferative Activity in Lung Cancer Cells. Angew Chem Int Ed Engl. 2021 Aug 2;60(32):17514-17521. DOI:10.1002/anie.202101864
Octanamide, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[4-(7-hydroxy-2-oxo-2H-1,3-benzoxazin-3(4H)-yl)phenyl]- Preparation Products And Raw materials
Tag:Octanamide, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[4-(7-hydroxy-2-oxo-2H-1,3-benzoxazin-3(4H)-yl)phenyl]-(2758431-97-7) Related Product Information
tert-Butyl 3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)(methyl)amino)azetidine-1-carboxylate 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-, 1,1-dimethylethyl ester-1-Piperazinecarboxylic acid, Octanamide, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[4-(7-hydroxy-2-oxo-2H-1,3-benzoxazin-3(4H)-yl)phenyl]- tert-Butyl (2-(2,6-dioxopiperidin-3-yl)-6-hydroxy-1-oxoisoindolin-4-yl)carbamate Carbamic acid, N-[6-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-1,6-dioxohexyl]amino]hexyl]-, 1,1-dimethylethyl ester 4-(2,6-dimethylphenoxy)-N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]butanamide