2(1H)-Pyridinone, 3-(2-bromophenyl)-5-(phenylamino)-

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2(1H)-Pyridinone, 3-(2-bromophenyl)-5-(phenylamino)- manufacturers
2(1H)-Pyridinone, 3-(2-bromophenyl)-5-(phenylamino)- Basic information
Product Name:2(1H)-Pyridinone, 3-(2-bromophenyl)-5-(phenylamino)-
Synonyms:2(1H)-Pyridinone, 3-(2-bromophenyl)-5-(phenylamino)-;p38-α MAPK-IN-4
CAS:2396754-57-5
MF:C17H13BrN2O
MW:341.2
EINECS:
Product Categories:
Mol File:2396754-57-5.mol
2(1H)-Pyridinone, 3-(2-bromophenyl)-5-(phenylamino)- Structure
2(1H)-Pyridinone, 3-(2-bromophenyl)-5-(phenylamino)- Chemical Properties
Boiling point 524.4±50.0 °C(Predicted)
density 1.503±0.06 g/cm3(Predicted)
pka11.48±0.10(Predicted)
Safety Information
MSDS Information
2(1H)-Pyridinone, 3-(2-bromophenyl)-5-(phenylamino)- Usage And Synthesis
Usesp38-α MAPK-IN-4 (Compound 69) is a selective p38α MAPK inhibitor with an IC50 of 1.5 μM. p38-α MAPK-IN-4 rapidly and strongly prevents the development of mechanical allodynia (MA) in vivo[1].
IC 50p38α MAPK: 1.5 μM (IC50)
References[1] Visseq A, et al. Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia. Eur J Med Chem. 2020 Feb 1;187:111917. DOI:10.1016/j.ejmech.2019.111917
2(1H)-Pyridinone, 3-(2-bromophenyl)-5-(phenylamino)- Preparation Products And Raw materials
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