| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
13636370518 |
| Email: |
shyysw007@163.com |
| Products Intro: |
Product Name:Visugromab (anti-GDF15)
CAS:2556646-63-8
Purity:ExactAb?, Low Endotoxin, Azide Free, Carrier Free, Validated Package:100μg Remarks:K14175
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| Company Name: |
Guangzhou Hongyuan Chemical Co.,Ltd
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| Tel: |
15817493340 |
| Email: |
981810490@qq.com |
| Products Intro: |
Product Name:Visugromab
CAS:2556646-63-8
Purity:95% Package:1mg;1g;100g
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| Company Name: |
Wuhan Chemstan Biotechnology Co., Ltd.
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| Tel: |
027-65317797 15926423062 |
| Email: |
422450190@qq.com |
| Products Intro: |
Product Name:Research Grade Visugromab
CAS:2556646-63-8
Purity:>95%;1mg/ml Package:100ug;1mg;20mg
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| Company Name: |
Biolab Reagents
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| Tel: |
027-65279366 18108604356 |
| Email: |
products@biolabreagent.com |
| Products Intro: |
Product Name:Research Grade Visugromab (DHJ48302)
CAS:2556646-63-8
Purity:PAGE:>95% Package:100ug;1mg
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| Company Name: |
Wuhan Acumen Bio-Technology Co.,ltd
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| Tel: |
027-027-16602739303 16602739303 |
| Email: |
673003916@qq.com |
| Products Intro: |
CAS:2556646-63-8
Purity:95%,98% HPLC Package:5G;1G
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| | Research Grade Visugromab (DHJ48302) Basic information |
| | Research Grade Visugromab (DHJ48302) Chemical Properties |
| form | Liquid | | color | Colorless to light yellow |
| | Research Grade Visugromab (DHJ48302) Usage And Synthesis |
| Uses | Visugromab (CTL-002) is a GDF-15 neutralizing IgG4 mAb. Visugromab has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors[1]. | | in vivo | Visugromab (up to 100 mg/kg; per week) shows no toxicity in the pre-clinical toxicology test of cynomolgus monkeys[2].
| | References | [1] Necchi A, et al. Neutralizing GDF-15 in muscle-invasive bladder cancer (MIBC): A neoadjuvant immunotherapy trial of visugromab (CTL-002) in combination with the anti-PD1 antibody nivolumab (NEO-GDFATHER)[J]. 2023.
[2] Melero I, et al. Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours. Nature. 2025 Jan;637(8048):1218-1227. DOI:10.1038/s41586-024-08305-z |
| | Research Grade Visugromab (DHJ48302) Preparation Products And Raw materials |
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