Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide

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Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
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Company Name: Nantong Hanfang Biotechnology Co. , Ltd.  
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Company Name: TargetMol Chemicals Inc.  
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Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide manufacturers
Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide Basic information
Product Name:Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide
Synonyms:Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide;PI3K/mTOR Inhibitor-8
CAS:2492376-85-7
MF:C23H22N8O4S
MW:506.54
EINECS:
Product Categories:
Mol File:2492376-85-7.mol
Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide Structure
Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide Chemical Properties
density 1.449±0.06 g/cm3(Predicted)
pka9.41±0.43(Predicted)
Safety Information
MSDS Information
Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide Usage And Synthesis
UsesPI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase[1].
IC 50PI3Kα: 0.46 nM (IC50); mTOR: 12 nM (IC50)
References[1] Han Y, et al. Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition. Bioorg Chem. 2020 Nov;104:104197. DOI:10.1016/j.bioorg.2020.104197
Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide Preparation Products And Raw materials
Tag:Thieno[3,2-d]pyrimidine-6-carboxylic acid, 2-(2-amino-5-pyrimidinyl)-4-(4-morpholinyl)-, 2-(4-methoxybenzoyl)hydrazide(2492376-85-7) Related Product Information
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