Deoxynojirimycin hydrochloride manufacturers
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| | Deoxynojirimycin hydrochloride Basic information |
| Product Name: | Deoxynojirimycin hydrochloride | | Synonyms: | DEOXYNOJIRIMICIN;DEOXYNOJIRIMYCIN HYDROCHLORIDE;DNJ, HCL;DNM;(2R,3R,4R,5S)-2-(HYDROXYMETHYL)-3,4,5-PIPERIDINETRIOL;(+)-1-DEOXYNOJIRIMYCIN HYDROCHLORIDE;1-DEOXYNOJIRIMYCIN HYDROCHLORIDE;1,5-DIDEOXY-1,5-IMINO-D-SORBITOL HYDROCHLORIDE | | CAS: | 73285-50-4 | | MF: | C6H13NO4.ClH | | MW: | 199.63 | | EINECS: | | | Product Categories: | All Inhibitors;Inhibitors | | Mol File: | 73285-50-4.mol |  |
| | Deoxynojirimycin hydrochloride Chemical Properties |
| Melting point | 195-196°C | | storage temp. | Inert atmosphere,2-8°C | | solubility | Water (Slightly) | | form | Powder | | color | White | | Water Solubility | Soluble in water at 20mg/ml | | BRN | 3563225 | | Stability: | Hygroscopic | | InChI | InChI=1/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5-,6-;/s3 | | InChIKey | ZJIHMALTJRDNQI-KOVNLEGCNA-N | | SMILES | C([C@H]1NC[C@@H]([C@H]([C@@H]1O)O)O)O.Cl |&1:1,4,5,6,r| | | CAS DataBase Reference | 73285-50-4 |
| Hazard Codes | Xi | | Risk Statements | 36/38 | | Safety Statements | 26-36-24/25-22 | | WGK Germany | 3 | | F | 10 | | Storage Class | 11 - Combustible Solids |
| | Deoxynojirimycin hydrochloride Usage And Synthesis |
| Description | 1-Deoxynojirimycin (1-DNJ) is an iminosugar that has been found in M. alba (mulberry) leaves and has diverse biological activities. It inhibits the activities of α- and β-glucosidase (IC50s = 35 and 71 μM, respectively). 1-DNJ (5 mM) reduces the formation of N-linked complex oligosaccharides in IEC-6 cells. It inhibits HIV-1 envelope-mediated membrane fusion in CEM cells when used at a concentration of 2 mM. 1-DNJ (1-100 μg/ml) reduces the invasion and migration of B16/F10 mouse melanoma cells. It improves glucose and insulin tolerance in db/db mice when administered intravenously at doses ranging from 20 to 80 mg/kg per day for four weeks. | | Chemical Properties | White Crystalline Solid | | Uses | natural chitin synthase inhibitor | | General Description | Specific glucosidase inhibitor, including trimming glucosidases I and II, that sequentially removes the three glucose residues from precursor Glc3Man9GlcNAc2 in N-linked glycan biosynthesis. | | Biochem/physiol Actions | Product does not compete with ATP. | | References | [1] KUO GAO. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing.[J]. Molecules, 2016, 21 1. DOI: 10.3390/molecules21111600
[2] ANA I AHUJA-CASARíN. Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors.[J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021: 138-146. DOI: 10.1080/14756366.2020.1847101
[3] JULIAN A. CODELLI. Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry[J]. Journal of the American Chemical Society, 2008, 130 34: 11486-11493. DOI: 10.1021/ja803086r
[4] MARIE-JEANNE PAPANDRéOU. The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step.[J]. Molecular Pharmacology, 2002, 61 1 1: 186-193. DOI: 10.1124/mol.61.1.186
[5] RAN-JUH WANG Miao L H Chun Hung Yang. 1-Deoxynojirimycin Inhibits Metastasis of B16F10 Melanoma Cells by Attenuating the Activity and Expression of Matrix Metalloproteinases-2 and -9 and Altering Cell Surface Glycosylation[J]. Journal of Agricultural and Food Chemistry, 2010, 58 16: 8988-8993. DOI: 10.1021/jf101401b
[6] QINGPU LIU. 1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice.[J]. Molecules, 2015, 20 1: 21700-21714. DOI: 10.3390/molecules201219794 |
| | Deoxynojirimycin hydrochloride Preparation Products And Raw materials |
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