9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl-

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9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl- Suppliers list
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9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl- manufacturers

  • M47
  • M47 pictures
  • $117.00
  • 2026-05-11
  • CAS:890808-56-7
  • Purity: 98.31%
  • Supply Ability: 10g
9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl- Basic information
Product Name:9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl-
Synonyms:9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl-;7-(4-Chlorophenyl)-2-(indoline-1-carbonyl)-1,7-dimethyl-7,8-dihydro-9H-furo[3,2-f]chromen-9-one
CAS:890808-56-7
MF:C28H22ClNO4
MW:471.93
EINECS:
Product Categories:
Mol File:890808-56-7.mol
9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl- Structure
9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl- Chemical Properties
Boiling point 661.6±55.0 °C(Predicted)
density 1.353±0.06 g/cm3(Predicted)
pka0.90±0.20(Predicted)
form Solid
color Light yellow to light brown
Safety Information
MSDS Information
9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl- Usage And Synthesis
UsesM47 is a small molecule that selectively destabilizes Cryptochrome 1 (CRY1) and increases degradation of the CRY1 in the nucleus. M47 enhances apoptosis in Ras-transformed P53-deficient mouse skin fibroblast lines and enhances life span in p53 knockout mice. M47 can be used in research of cancer[1].
in vivo

M47 (5-1000 mg/kg; i.p.; daily, for 5 d; C57BL/6J mice and p53 gene knockout C57BL/6J mice) selectively reduces the half-life of CRY1 and is well tolerated with a good pharmacokinetic profile in vivo and enhances apoptosis[1].

Animal Model:C57BL/6J mice and p53 gene knockout C57BL/6J mice[1]
Dosage:5, 50, 300 and 1000 mg/kg
Administration:intraperitoneal injection, daily, for 5 days
Result:Prolonged the life span of p53 gene knockout mice.
References[1] Gul S, et, al. Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice. Nat Commun. 2022 Nov 8;13(1):6742. DOI:10.1038/s41467-022-34582-1
9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl- Preparation Products And Raw materials
Tag:9H-Furo[3,2-f][1]benzopyran-9-one, 7-(4-chlorophenyl)-2-[(2,3-dihydro-1H-indol-1-yl)carbonyl]-7,8-dihydro-1,7-dimethyl-(890808-56-7) Related Product Information
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