- Protosappanin A
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- $85.00
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2026-07-27
- CAS:102036-28-2
- Purity: 99.82%
- Supply Ability: 10g
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| | protosappanin A Basic information |
| Product Name: | protosappanin A | | Synonyms: | protosappanin A;Sappanol B;3,10,11-Trihydroxy-6H-dibenz[b,d]oxocin-7(8H)-one;PROTOSAPPANIN A (PTA);6H-Dibenz[b,d]oxocin-7(8H)-one, 3,10,11-trihydroxy-;3,10,11-Trihydroxy-6H-dibenzo[b,d]oxocin-7(8H)-one;Protosappanin A,inhibit,JAK,Inhibitor,STAT,Janus kinase;Protosappanin A, 10 mM in DMSO | | CAS: | 102036-28-2 | | MF: | C15H12O5 | | MW: | 272.25 | | EINECS: | | | Product Categories: | | | Mol File: | 102036-28-2.mol |  |
| | protosappanin A Chemical Properties |
| Melting point | 254-255 °C | | Boiling point | 613.1±55.0 °C(Predicted) | | density | 1.476±0.06 g/cm3(Predicted) | | storage temp. | 4°C, away from moisture and light | | solubility | Soluble in DMSO | | form | Solid | | pka | 9.01±0.20(Predicted) | | color | White to off-white |
| | protosappanin A Usage And Synthesis |
| Description | Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3. | | Uses | Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3[1]. | | Definition | ChEBI:
Protosappanin A is a member of catechols. It has a role as a metabolite. | | IC 50 | JAK2; STAT3 | | References | [1] Wang LC, et al. Protosappanin A exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Chin J Nat Med. 2017 Sep;15(9):674-679. DOI:10.1016/S1875-5364(17)30096-1
[2] Zeng KW, et al. Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll-like receptor-4 in lipopolysaccharide-induced BV-2 microglia. Int Immunopharmacol, 2012, 14(4): 558- 569. DOI:10.1016/j.intimp.2012.09.004 |
| | protosappanin A Preparation Products And Raw materials |
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